Valproic Acid

  

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Valproic Acid

Definition: Valproic Acid

Valproic Acid

Noun

1. Anticonvulsant (trade name Depokene) used to prevent some kinds of seizures.

Source: WordNet 1.7.1 Copyright © 2001 by Princeton University. All rights reserved.
 



Specialty Definitions: Valproic Acid

DomainDefinitions

Health

A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GABA levels in the brain or by altering the properties of voltage dependent sodium channels. (references)

Source: compiled by the editor from various references; see credits.

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Specialty Definition: Valproic acid

(From Wikipedia, the free Encyclopedia)

Valproic acid or 2-Propylpentanoic acid is (CH3CH2CH2CH(CH2CH2CH3)COOHOH .

Sodium valproate (also known as Valproate, or VPA) is a sodium salt of valproic acid.

Divalproex Sodium, sold by Abbott Laboratories under the trade name of Depakote is the semisodium salt of valproic acid, made by combining sodium valproate with valproic acid to form a chemical complex which contains half the sodium of an equivalent dose of sodium valproate.

Valproic acid, delivered in either of these forms, is a anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder; but also used to treat migraine headaches and schizophrenia. In epileptics, valproic acid is used to control absence seizures, tonic-clonic seizures (grand mal), complex partial seizures, and the seizures associated with Lennox-Gastaut syndrome.

Valproate is believed to affect GABA receptors in the human brain.

Side Effects

Common side effects are dyspepsia and/or weight-gain. Less common are dizziness, drowsiness, hair-loss, headaches, nausea, sedation and tremors,

Valproic acid can also rarely cause blood dyscrasia, impaired liver function, jaundice, thrombocytopenia, and prolonged coagulation times. In ~5% of pregnant users, valproic acid will cross the placenta and cause congenital anomalies.

There have also been reports of cognitive dysfunction, Parkinsonian syndrome and even pseudoatrophic brain changes in long-term treatment with valproic acid.

Source: adapted by the editor from Wikipedia, the free encyclopedia under a copyleft GNU Free Documentation License (GFDL) from the article "Valproic acid."

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Synonym: Valproic Acid

Synonym: Depokene (n). (additional references)

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Non-Fiction Usage: Valproic Acid

SubjectTopicQuote

Health

Some cluster patients can prevent attacks by taking propranolol, methysergide, valproic acid, verapamil, or lithium carbonate. (references)

Baclofen, clonazepam, gabapentin, and valproic acid may also be effective and may be used in combination to achieve pain relief. (references)

Source: compiled by the editor from ICON Group International, Inc.; see credits.

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Expressions: Valproic Acid

Expressions using "valproic acid": Valproic Acid and Derivatives Valproic Acid Derivatives. Additional references.

Source: compiled by the editor from various references; see credits.

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Frequency of Internet Keywords: Valproic Acid

The following statistics estimate the number of searches per day across the major English-language search engines as identified by various trade publications. Hyperlinks lead to commercial use of the expression at Amazon.com.
 
ExpressionFrequency
per Day

valproic acid

80

valproic acid side effects

6
Source: compiled by the editor from various references; see credits.

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Modern Translations: Valproic Acid

Language Translations for "valproic acid"; alternative meanings/domain in parentheses.

Danish

  

valproesyre. (various references)

   

Dutch

  

valproezuur. (various references)

   

Finnish

  

valproiinihappo. (various references)

   

French

  

acide valproïque. (various references)

   

German

  

Valproesäure. (various references)

   

Italian

  

acido valproico. (various references)

   

Pig Latin

  

alproicvay aciday.(various references)

   

Portuguese

  

ácido valpro'co. (various references)

   

Spanish

  

ácido valproico. (various references)

   

Swedish

  

valpronsyra. (various references)

Source: compiled by the editor from various translation references.

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Anagrams: Valproic Acid

Scrabble® Enable2K-Verified Anagrams

Words within the letters "a-a-c-c-d-i-i-l-o-p-r-v"

-4 letters: ovicidal, vicarial.

-5 letters: acaroid, accidia, caloric, caporal, caracol, cardiac, carioca, carload, codicil, cordial, cricoid, diploic, dipolar, ovarial, ovipara, parodic, picador, placard, placoid, radical, ravioli, variola, vocalic.

Source: compiled by the editor from various references; see credits.

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Alternative Orthography: Valproic Acid


Hexadecimal (or equivalents, 770AD-1900s) (references)

56 61 6C 70 72 6F 69 63      41 63 69 64

Leonardo da Vinci (1452-1519; backwards) (references)

    

Binary Code (1918-1938, probably earlier) (references)

01010110 01100001 01101100 01110000 01110010 01101111 01101001 01100011 00100000 01000001 01100011 01101001 01100100

HTML Code (1990) (references)

&#86 &#97 &#108 &#112 &#114 &#111 &#105 &#99 &#32 &#65 &#99 &#105 &#100

ISO 10646 (1991-1993) (references)

0056 0061 006C 0070 0072 006F 0069 0063      0041 0063 0069 0064

Encryption (beginner's substitution cypher): (references)

5667788284817569235697570

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INDEX

1. Definition
2. Synonyms
3. Quotations: Non-fiction
4. Expressions
5. Expressions: Internet
6. Translations: Modern
7. Anagrams
8. Orthography
9. Bibliography


  

Copyright © Philip M. Parker, INSEAD. Terms of Use.