TUMOR SUPPRESSOR GENE

A tumor suppressor gene is a gene that reduces the probability that a cell in a multicellular organism will turn into a tumor cell. A mutation or deletion of such a gene will increase the probability of a tumor. In that way, a tumor suppressor gene is similar to an oncogene.

Tumor suppressor genes, or more precisely, the proteins they code for, have a dampening or repressive effect on the regulation of the cell cycle. This is basically done by the tumor suppression genes/proteins in three ways :

Repression of genes that are essential for the continuing of the cell cycle. If these genes are not expressed, the cell cycle will not continue, effectively inhibiting cell division.
Coupling the cell cycle to DNA damage. As long as there is damaged DNA in the cell, it should not divide. If the damage can be repaired, the cell cycle can continue.
If the damage can not be repaired, the cell should initiate apoptosis, the programmed cell death, to remove the threat it poses for the greater good of the organism.

The first tumor suppressor protein discovered was the pRb protein in human retinoblastoma. An important tumor suppressor is the p53 gene.

See also : Cancer -- signal transduction

Crosswords: TUMOR SUPPRESSOR GENE

Specialty definitions using "TUMOR SUPPRESSOR GENE": Li-Fraumeni Syndrome ♦ p53 gene, Protein p16 ♦ Retinoblastoma Protein. (references)

Source: compiled by the editor from various references; see credits.

Commercial Usage: TUMOR SUPPRESSOR GENE

Domain	Title
Books	Von Hippel-Lindau Disease Tumor Suppressor Gene (Medical Intelligence Unit Series) (reference) (more book examples)
Source: compiled by the editor from various references; see credits.

Non-Fiction Usage: TUMOR SUPPRESSOR GENE

Subject	Topic	Quote
Health		One particular tumor suppressor gene codes for a protein called "p53" that can trigger cell suicide (apoptosis). (references)
		For example, colon cancer can begin with a defect in a tumor suppressor gene that allows excessive cell proliferation. (references)
		The loss of a tumor suppressor gene function is like having a brake pedal that does not function properly, thereby allowing the cell to grow and divide continually. (references)
Source: compiled by the editor from ICON Group International, Inc.; see credits.

Frequency of Internet Keywords: TUMOR SUPPRESSOR GENE

Misspellings: TUMOR SUPPRESSOR GENE

Alternative Orthography: TUMOR SUPPRESSOR GENE

Hexadecimal (or equivalents, 770AD-1900s) (references)

54 55 4D 4F 52 53 55 50 50 52 45 53 53 4F 52 47 45 4E 45

Leonardo da Vinci (1452-1519; backwards) (references)

Binary Code (1918-1938, probably earlier) (references)

01010100 01010101 01001101 01001111 01010010 00100000 01010011 01010101 01010000 01010000 01010010 01000101 01010011 01010011 01001111 01010010 00100000 01000111 01000101 01001110 01000101

HTML Code (1990) (references)

&#84 &#85 &#77 &#79 &#82 &#32 &#83 &#85 &#80 &#80 &#82 &#69 &#83 &#83 &#79 &#82 &#32 &#71 &#69 &#78 &#69

ISO 10646 (1991-1993) (references)

0054 0055 004D 004F 0052 0053 0055 0050 0050 0052 0045 0053 0053 004F 0052 0047 0045 004E 0045

Encryption (beginner's substitution cypher): (references)

TUMOR SUPPRESSOR GENE

Specialty Definition: TUMOR SUPPRESSOR GENE

Health

Specialty Definition: Tumor suppressor gene

Crosswords: TUMOR SUPPRESSOR GENE

Commercial Usage: TUMOR SUPPRESSOR GENE

Books

Non-Fiction Usage: TUMOR SUPPRESSOR GENE

Health

Frequency of Internet Keywords: TUMOR SUPPRESSOR GENE

tumor suppressor gene

Misspellings: TUMOR SUPPRESSOR GENE

Misspellings

Alternative Orthography: TUMOR SUPPRESSOR GENE

54 55 4D 4F 52 53 55 50 50 52 45 53 53 4F 52 47 45 4E 45

01010100 01010101 01001101 01001111 01010010 00100000 01010011 01010101 01010000 01010000 01010010 01000101 01010011 01010011 01001111 01010010 00100000 01000111 01000101 01001110 01000101

&#84 &#85 &#77 &#79 &#82 &#32 &#83 &#85 &#80 &#80 &#82 &#69 &#83 &#83 &#79 &#82 &#32 &#71 &#69 &#78 &#69

0054 0055 004D 004F 0052 0053 0055 0050 0050 0052 0045 0053 0053 004F 0052 0047 0045 004E 0045

5455474952253555050523953534952241394839

INDEX

Domain	Definition
Health	Genes in the body that can suppress or block the development of cancer. (references)
Source: compiled by the editor from various references; see credits.

Expression	Frequency per Day
tumor suppressor gene	5
Source: compiled by the editor from various references; see credits.

Misspellings
	"TUMOR SUPPRESSOR GENE" is suggested in spellcheckers for the following: tumour suppressor gene. (additional references)
Source: compiled by the editor, based on several corpora (additional references).