Copyright © Philip M. Parker, INSEAD. Terms of Use.
Definition: Tumor Necrosis Factor |
Tumor Necrosis FactorNoun1. A proinflammatory cytokine that is produced by white blood cells (monocytes and macrophages); has an antineoplastic effect but causes inflammation (as in rheumatoid arthritis). Source: WordNet 1.7.1 Copyright © 2001 by Princeton University. All rights reserved. |
| Domain | Definition |
Health | Serum glycoprotein produced by activated macrophages and other mammalian mononuclear leukocytes which has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. It mimics the action of endotoxin but differs from it. It has a molecular weight of less than 70,000 kDa. (references) |
Source: compiled by the editor from various references; see credits. | |
Synonym: Tumor Necrosis FactorSynonym: tumour necrosis factor (n). (additional references) |
Crosswords: Tumor Necrosis Factor |
| English words defined with "tumor necrosis factor": anti-TNF compound. (references) |
| Specialty definitions using "tumor necrosis factor": Antigens, CD40 ♦ Lymphotoxin ♦ Receptors, Tumor Necrosis Factor. (references) |
| Domain | Title |
Books | |
Source: compiled by the editor from various references; see credits. | |
| Thumbnail | Description & Credit |  | The patient is a 53 year old woman with metastatic melanoma to multiple subcutaneous sites and retroperitoneum. She was treated with tumor infiltrating lymphocytes (TILs) transduced with the gene for tumor necrosis factor (TNF). Pretreatment biopsy shows multiple live melanoma cells with little lymphoid infiltrate. Following treatment with TNF gene modified TILs plus interleukin-2, a biopsy of another lesion showed massive coagulative necrosis of the tumor with no viable tumor seen. This is a typical picture seen in experimental animals treated with tumor necrosis factor. This patient has had a substantial objective response that is currently ongoing at nine months following initiation of treatment. Credit: Unknown photographer/artist. |
Source: pictures compiled by the editor from various references; see picture credits. | |||
| Subject | Topic | Quote |
Health | There is evidence that certain cytokines are involved in the pathogenesis of HPS. Tumor necrosis factor (TNF) alpha or beta and interleukin 2 (IL-2) seem especially important. (references) | |
Source: compiled by the editor from ICON Group International, Inc.; see credits. | ||
| The following statistics estimate the number of searches per day across the major English-language search engines as identified by various trade publications. Hyperlinks lead to commercial use of the expression at Amazon.com. |
| Expression | Frequency per Day |
tumor necrosis factor | 22 |
tumor necrosis factor alpha | 5 |
| Source: compiled by the editor from various references; see credits. | |
| Language | Translations for "tumor necrosis factor"; alternative meanings/domain in parentheses. | ||||||||||||||||||||||
Danish | tumor-nekrose-faktor (tumour necrosis factor). (various references) | ||||||||||||||||||||||
Dutch | tumor-necrose-factor (tumour necrosis factor). (various references) | ||||||||||||||||||||||
Finnish | tuumorinekroositekijä (tumour necrosis factor). (various references) | ||||||||||||||||||||||
French | facteur nécrosant les tumeurs (tumour necrosis factor), facteur de nécrose des tumeurs (tumour necrosis factor). (various references) | ||||||||||||||||||||||
German | Tumor-Nekrose-Faktor (tumour necrosis factor). (various references) | ||||||||||||||||||||||
Greek | παράγοντας νέκρωσης όγκων (tumour necrosis factor). (various references) | ||||||||||||||||||||||
Italian | fattore necrotizzante i tumori (tumour necrosis factor), fattore di necrosi tumorale (tumour necrosis factor). (various references) | ||||||||||||||||||||||
Pig Latin | umortay ecrosisnay actorfay factor de necrose tumoral (tumour necrosis factor). (various references) factor de necrosis tumoral (tumour necrosis factor). (various references) tumour necrosis factor (tumour necrosis factor), tumor necrosis factor (tumour necrosis factor). (various references) | ||||||||||||||||||||||
Scrabble® Enable2K-Verified Anagrams | |
| Words within the letters "a-c-c-e-f-i-m-n-o-o-o-r-r-r-s-s-t-t-u" | |
-5 letters: reconstructors. | |
| Source: compiled by the editor from various references; see credits. SCRABBLE® is a registered trademark. All intellectual property rights in and to the game are owned in the U.S.A and Canada by Hasbro Inc., and throughout the rest of the world by J.W. Spear & Sons Limited of Maidenhead, Berkshire, England, a subsidiary of Mattel Inc. Mattel and Spear are not affiliated with Hasbro. | |
| 1. Definition 2. Synonyms 3. Crosswords 4. Usage: Commercial | 5. Images: Photo Album 6. Quotations: Non-fiction 7. Expressions: Internet 8. Translations: Modern | 9. Anagrams 10. Bibliography |
Copyright © Philip M. Parker, INSEAD. Terms of Use.
