Sticky End

Domain	Definition
Medicine	The staggered ends of complementary sequences of DNA which result from cleavage by a restriction enzyme. They are so called because they will combine with complementary sequences produced by the same enzyme on the DNA of a suitable vector. Source: European Union. (references)
Source: compiled by the editor from various references; see credits.

Specialty Definition: Sticky end/blunt end

Sticky end and blunt end are biological jargon describing the two possible configurations that may result from the breaking of double stranded DNA. DNA exhibits a stabilizing interaction between complementary base pairs, providing specificity to the pairing of two strands of DNA. If two complementary strands of DNA are of equal length, then they will terminate in a blunt end, as in the following example:

5'-CpTpGpApTpCpTpGpApCpTpGpApTpGpCpGpTpApTpGpCpTpApGpT-3' 3'-GpApCpTpApGpApCpTpGpApCpTpApCpGpCpApTpApCpGpApTpCpA-5'

However, if one strand extends beyond the complementary region, then the DNA is said to possess an overhang:

5'-ApTpCpTpGpApCpT-3' 3'-TpApGpApCpTpGpApCpTpApCpG-5'

If another DNA fragment exists with a complementary overhang, then these two overhangs will tend to associate with each other and each strand is said to possess a sticky end:

5'-ApTpCpTpGpApCpT GpApTpGpCpGpTpApTpGpCpT-3' 3'-TpApGpApCpTpGpApCpTpApCpG CpApTpApCpGpA-5' becomes 5'-ApTpCpTpGpApCpT GpApTpGpCpGpTpApTpGpCpT-3' 3'-TpApGpApCpTpGpApCpTpApCpG CpApTpApCpGpA-5'

The two fragments may then be covalently bonded by DNA ligase. Blunt ends may be ligated together, but the reaction is significantly slower. These terms are most commonly used to describe the product of a restriction enzyme digestion of DNA.

Expression: Sticky End

Modern Translation: Sticky End

Language		Translations for "sticky end"; alternative meanings/domain in parentheses.
Czech		špatnì skonèit (come to a sticky end). (various references)

Danish		kohæsiv ende (cohesive end), klæbrig ende (cohesive end). (various references)

Dutch		rafeluiteinde (cohesive end). (various references)

Finnish		toisiinsa tarttuvat päät (cohesive end). (various references)

French		extrémité collante, extrémité cohésive, bout collant. (various references)

German		kohäsives Ende (cohesive end), klebriges Ende (cohesive end). (various references)

Greek		κολλώδες άκρο (cohesive end), συμπληρωματικό άκρο (cohesive end). (various references)

Hungarian		szomorú vége van (to come to a sticky end), gyászos vége van (to come to a sticky end). (various references)

Italian		terminazione coesiva (cohesive end), estremit� coesiva (cohesive end). (various references)

Pig Latin		ickystay enday

Portuguese		extremidade coesiva (cohesive end). (various references)

Spanish		extremo cohesivo (cohesive end). (various references)

Swedish		kohesiv ände (cohesive end), klibbig ände (cohesive end). (various references)
Source: compiled by the editor from various translation references.

Anagrams: Sticky End

Scrabble® Enable2K-Verified Anagrams
	Words within the letters "c-d-e-i-k-n-s-t-y"
	-1 letter: syndetic.
	-2 letters: cystein, cystine, density, destiny, deticks, dickens, dickeys, dinkeys, kidneys, kindest, snicked, sticked.
	-3 letters: detick, dickey, dickys, dinkey, edicts, encyst, incest, insect, kidney, nicest, nicety, nicked, sicked, sicken, skited, sticky, stinky, synced, syndet, syndic, teinds, ticked.
	-4 letters: cedis, cents, cesti, cines, cited, cites, decks, deist, deity, dents, dices, dicey, dicks, dicky, dicty, diets.
	Words containing the letters "c-d-e-i-k-n-s-t-y"
	+1 letter: dyskinetic.
Source: compiled by the editor from various references; see credits. SCRABBLE® is a registered trademark. All intellectual property rights in and to the game are owned in the U.S.A and Canada by Hasbro Inc., and throughout the rest of the world by J.W. Spear & Sons Limited of Maidenhead, Berkshire, England, a subsidiary of Mattel Inc. Mattel and Spear are not affiliated with Hasbro.

Sticky End

Definition: Sticky End

Sticky End

Noun

Specialty Definition: Sticky End

Medicine

Specialty Definition: Sticky end/blunt end

Synonym: Sticky End

Expression: Sticky End

Modern Translation: Sticky End

Czech

Danish

Dutch

Finnish

French

German

Greek

Hungarian

Italian

Pig Latin

Portuguese

Spanish

Swedish

Anagrams: Sticky End

Scrabble® Enable2K-Verified Anagrams

INDEX

Expression using "sticky end": come to a sticky end. Additional references.
Source: compiled by the editor from various references; see credits.