HOLOPROSENCEPHALY

Domain	Definition
Health	Anterior midline brain, cranial, and facial malformations resulting from the failure of the embryonic prosencephalon to undergo segmentation and cleavage. Alobar prosencephaly is the most severe form and features anophthalmia; cyclopia; severe mental retardation; cleft lip; cleft palate; seizures; and microcephaly. Semilobar holoprosencepaly is characterized by hypotelorism, microphthalmia, coloboma, nasal malformations, and variable degrees of mental retardation. Lobar holoprosencephaly is associated with mild (or absent) facial malformations and intellectual abilities that range from mild mental retardation to normal. Holoprosencephlay is associated with chromosome abnormalities. (references)
Medicine	A disorder characterised by the failure of the prosencephalon-the forebrain of the embryo-to develop. Source: European Union. (references)
Source: compiled by the editor from various references; see credits.

Commercial Usage: HOLOPROSENCEPHALY

Domain	Title
References	The Official Parent's Sourcebook on Holoprosencephaly (reference) (more reference examples)
Source: compiled by the editor from various references; see credits.

Non-Fiction Usage: HOLOPROSENCEPHALY

Subject	Topic	Quote
Health		There are three classifications of holoprosencephaly. (references)
		There is no standard course of treatment for holoprosencephaly. (references)
		In octocephaly, agnathia may occur alone or together with holoprosencephaly. (references)
Source: compiled by the editor from ICON Group International, Inc.; see credits.

Frequency of Internet Keywords: HOLOPROSENCEPHALY

Modern Translation: HOLOPROSENCEPHALY

Language		Translations for "HOLOPROSENCEPHALY"; alternative meanings/domain in parentheses.
Danish		holoprosencephali (arhinencephaly). (various references)

Dutch		holoprosencefalie (arhinencephaly). (various references)

Finnish		holoprosenkefalia (arhinencephaly). (various references)

French		holoprosencéphalie. (various references)

German		Holoprosenzephalie (arhinencephaly). (various references)

Greek		ολοπροσεγγεφαλία (arhinencephaly). (various references)

Italian		oloprosencefalia (alobar holoprosencephaly, arhinencephaly). (various references)

Pig Latin		oloprosencephalyhay

Portuguese		holoprosencefalia alobar (alobar holoprosencephaly). (various references)

Spanish		holoprosencefalia (arhinencephaly). (various references)
Source: compiled by the editor from various translation references.

Anagrams: HOLOPROSENCEPHALY

Scrabble® Enable2K-Verified Anagrams
	Words within the letters "a-c-e-e-h-h-l-l-n-o-o-o-p-p-r-s-y"
	-5 letters: anchorpeople.
Source: compiled by the editor from various references; see credits. SCRABBLE® is a registered trademark. All intellectual property rights in and to the game are owned in the U.S.A and Canada by Hasbro Inc., and throughout the rest of the world by J.W. Spear & Sons Limited of Maidenhead, Berkshire, England, a subsidiary of Mattel Inc. Mattel and Spear are not affiliated with Hasbro.