Zollinger-Ellison Syndrome

Definition: Zollinger-Ellison Syndrome

Zollinger-Ellison Syndrome

Noun

1. Syndrome consisting of intractable peptic ulceration with gastric hypersecretion and hyperacidity.

Specialty Definition: Zollinger-Ellison Syndrome

Domain	Definition
Health	A disorder in which tumors of the pancreatic islet cells produce large amounts of gastrin (a hormone), leading to excess acid in the stomach and, possibly, a peptic ulcer (ulcer of the stomach or the upper part of the small intestine). (references)
Medicine	An extremely virulent ulcer diathesis with excessive gastric acid secretion and diarrhoea. Source: European Union. (references)
Source: compiled by the editor from various references; see credits.

Specialty Definition: Zollinger-Ellison Syndrome

excessive ulceration of the upper gastrointestinal tract (stomach, duodenum, jejunum) caused by over-secretion of the hormone gastrin, usually from a gastrinoma which is usually benign but very occasionally is malignant.Zollinger-Ellison syndrome is a disorder where increased levels of the hormone gastrin are produced, causing the stomach to produce excess acid.

Slow-growing tumours in the pancreas or the duodenem, called gastrinomas produce too much gastrin in the blood stream. Gastrin works on stomach parietal cells causing them to secrete more hydrogen ions into the stomach lumen. The increase acid leads to peptic ulcers in the stomach and duodenem.

Proton pump inhibitors and H2 blockers are used to slow down acid secretion. If possible the tumours should be removed, or treated with chemotherapy.

Commercial Usage: Zollinger-Ellison Syndrome

Domain	Title
References	The Official Patient's Sourcebook on Zollinger-Ellison Syndrome (reference) (more reference examples)
Source: compiled by the editor from various references; see credits.

Non-Fiction Usage: Zollinger-Ellison Syndrome

Subject	Topic	Quote
Health		Patients with Zollinger-Ellison syndrome may also have dumping syndrome. (references)
		Taken by mouth, these have proven effective in controlling most cases of Zollinger-Ellison syndrome. (references)
		The ulcers caused by Zollinger-Ellison syndrome are more painful and less responsive to treatment than ordinary peptic ulcers. (references)
Source: compiled by the editor from ICON Group International, Inc.; see credits.

Modern Translation: Zollinger-Ellison Syndrome

Language		Translations for "Zollinger-Ellison syndrome"; alternative meanings/domain in parentheses.
Danish		Zollinger-Ellisons syndrom. (various references)

Dutch		syndroom van Zollinger-Ellison, recidiverende digestieve ulcera. (various references)

Finnish		Zollinger-Ellisonin oireyhtymä. (various references)

French		syndrome de Zollinger-Ellison. (various references)

Greek		σύνδρομο Zollinger-Ellison. (various references)

Italian		sindrome di Zollinger-Ellison. (various references)

Pig Latin		ollinger-ellisonzay yndromesay

Spanish		síndrome de Zollinger-Ellison. (various references)
Source: compiled by the editor from various translation references.

Zollinger-Ellison Syndrome

Definition: Zollinger-Ellison Syndrome