Copyright © Philip M. Parker, INSEAD. Terms of Use.
Definition: Wilson's Disease |
Wilson's DiseaseNoun1. A rare inherited disorder of copper metabolism; copper accumulates in the liver and then in the red blood cells and brain. Source: WordNet 1.7.1 Copyright © 2001 by Princeton University. All rights reserved. |
Synonym: Wilson's DiseaseSynonym: hepatolenticular degeneration (n). (additional references) |
(From Wikipedia, the free Encyclopedia)
Wilson's disease requires lifelong treatment. If the disorder is detected early and treated correctly, a person with Wilson's disease can enjoy completely normal health.
Original text is from a public domain source found at: http://www.niddk.nih.gov/health/digest/summary/wilson/wilson.htmDescription
The liver of a person who has Wilson's disease expresses a mutant form of the protein called Wilson's disease protein,or WND. WND is a copper transporting protein that exports copper from liver cells. The mutant form of WND expressed in people with Wilson's disease inhibits the release of copper into bile. Bile is a liquid produced by the liver that helps with digestion. As the intestines absorb copper from food, the copper builds up in the liver and injures liver tissue. Eventually, the damage causes the liver to release the copper directly into the bloodstream, which carries the copper throughout the body. The copper buildup leads to damage in the kidneys, brain, and eyes. If not treated, Wilson's disease can cause severe brain damage, liver failure, and death. Symptoms
Symptoms usually appear between the ages of 6 and 20 years, but sometimes not until the age of 30, and in rare instances up to age 50. The most characteristic sign is the Kayser-Fleischer ring--a rusty brown ring around the cornea of the eye that can be seen only through an eye exam. Other signs depend on whether the damage occurs in the liver, blood, central nervous system, urinary system, or musculoskeletal system. Many signs would be detected only by a doctor, like swelling of the liver and spleen; fluid buildup in the lining of the abdomen; anemia; low platelet and white blood cell count in the blood; high levels of amino acids, protein, uric acid, and carbohydrates in urine; and softening of the bones. Some symptoms are more obvious, like jaundice, which appears as yellowing of the eyes and skin; vomiting blood; speech and language problems; tremors in the arms and hands; and rigid muscles. Diagnosis
Wilson's disease is diagnosed through tests that measure the amount of copper in the blood, urine, and liver. An eye exam would detect the Kayser-Fleischer ring. Treatment
The disease is treated with lifelong use of D-penicillamine or trientine hydrochloride, drugs that help remove copper from tissue. Patients will also need to take vitamin B6 and follow a low-copper diet, which means avoiding mushrooms, nuts, chocolate, dried fruit, liver, and shellfish. Taking extra zinc may be helpful in blocking the intestines' absorption of copper.
Source: adapted by the editor from Wikipedia, the free encyclopedia under a copyleft GNU Free Documentation License (GFDL) from the article "Wilson's disease."
Crosswords: Wilson's Disease |
| English words defined with "Wilson's disease": Cuprimine ♦ Kayser-Fleischer ring ♦ penicillamine. (references) |
| Specialty definitions using "Wilson's disease": Rats, Inbred LEC, Rats, Long-Evans. (references) |
| Domain | Title |
References | |
Books | |
Source: compiled by the editor from various references; see credits. | |
| Subject | Topic | Quote |
Health | Wilson's disease causes the body to retain copper. (references) | |
Sternlieb, I. The outlook for the diagnosis of Wilson's disease. (references) | ||
Brewer, GJ. Practical Recommendations and New Therapies for Wilson's Disease. (references) | ||
Source: compiled by the editor from ICON Group International, Inc.; see credits. | ||
| Language | Translations for "Wilson's disease"; alternative meanings/domain in parentheses. | ||||||||||
Danish | Wilsons sygdom (Wilson disease). (various references) | ||||||||||
Dutch | ziekte van Wilson (hepatolenticular degeneration, Wilson disease, Wilson syndrome), progressieve hepatolenticulaire degeneratie (Wilson disease), degeneratio hepatolenticularis (Wilson disease). (various references) | ||||||||||
Finnish | Wilsonin tauti (Wilson disease), hepatolentikulaarinen degeneraatio (Wilson disease). (various references) | ||||||||||
French | maladie Wilson (Wilson disease), maladie de Wilson (Wilson disease). (various references) | ||||||||||
Greek | νόσος Wilson (hepatolenticular degeneration, Wilson disease, Wilson syndrome). (various references) | ||||||||||
Italian | morbo di Wilson (Wilson disease), malattia di Wilson (Wilson disease). (various references) | ||||||||||
Pig Latin | ilson'sway iseaseday enfermedad de Wilson (Wilson disease). (various references) | ||||||||||
| Language | Period | Translations |
| Latin | 500 BCE-Modern | degeneratio hepatolenticularis. (various references) |
| Source: compiled by the editor from various references. | ||
Scrabble® Enable2K-Verified Anagrams | |
| Words within the letters "'-a-d-e-e-i-i-l-n-o-s-s-s-s-w" | |
-4 letters: dailinesses, solidnesses. | |
-5 letters: eledoisins, oilinesses, seasonless, slownesses, snowslides, wildnesses, wilinesses, windlasses. | |
| Source: compiled by the editor from various references; see credits. SCRABBLE® is a registered trademark. All intellectual property rights in and to the game are owned in the U.S.A and Canada by Hasbro Inc., and throughout the rest of the world by J.W. Spear & Sons Limited of Maidenhead, Berkshire, England, a subsidiary of Mattel Inc. Mattel and Spear are not affiliated with Hasbro. | |
Hexadecimal (or equivalents, 770AD-1900s) (references)57 69 6C 73 6F 6E 27 73 44 69 73 65 61 73 65 |
| Leonardo da Vinci (1452-1519; backwards) (references)
|
Binary Code (1918-1938, probably earlier) (references)01010111 01101001 01101100 01110011 01101111 01101110 00100111 01110011 00100000 01000100 01101001 01110011 01100101 01100001 01110011 01100101 |
HTML Code (1990) (references)W i l s o n ' s   D i s e a s e |
ISO 10646 (1991-1993) (references)0057 0069 006C 0073 006F 006E 0027 0073 0044 0069 0073 0065 0061 0073 0065 |
Encryption (beginner's substitution cypher): (references)577578858180985238758571678571 |
| 1. Definition 2. Synonyms 3. Crosswords 4. Usage: Commercial | 5. Quotations: Non-fiction 6. Translations: Modern 7. Translations: Ancient 8. Anagrams | 9. Orthography 10. Bibliography |
Copyright © Philip M. Parker, INSEAD. Terms of Use.
| Note to the press & webmasters - this dictionary can be linked, indexed, or referred to using the following non-English expressions: woordeboek, fjalor, معجم, قاموس, diccionariu, речник, diccionari, diksyonario, diksinario, 字典, gérlyver, slovník, ordbog, woordenboek, shimiyuc p'anca, orðabók, orðbók, dictionnaire, wurdboek, wörterbuch, λεξικό, אוצר מילים, szótár, uqausiit tukingit, dizionario, 字引 , じい, じびき, じて", ディクショナリー , じり", じしょ, '"かい, ディクショナリ , 사 , dizionari, recnik, fockleyr, dikshonario, słownik, dicionário, dicţionar, dicziunari, словарь, lolomi fefiloi, foclair, abardair, faclair, briathrachan, pukuntau, leksikon, rečnik, vocabbulariu, diccionario, sí-chazamagâma, ordbok, lexikon, พจนานุกรม, sözlük, ansiklopedik sözlük, словник, довідник, có tính chất sách vở, geirlyfr, geiriadur, for dictionary; definisie, qartësi, përcaktim, saktësi, الوضوحية في الشيء, حد, تحديد, تعريف, التحديد, الإيضاحية, яснота, сила, очертания, дефиниция, 定義 , 定义, definice, deskriptordefinition, definitie, määritelmä, définition, ορισμός, "'"ר", "'בל", meghatározás, definíció, definizione, 確定 , ディーゼル電気車 , デ'ドロ酢酸 , デフィニション , ディフィニション , ていぎ, かくてい, 의, geyrid, meenaghey, keeayllaght, baght, definishon, definição, definiţie, determinare, definire, определение, definicija, definición, definition, açıklama, belirleme, belirtme, kesinleştirme, tanım, tarif, seçiklik, tanımlama, чіткість, тлумачення, виразність, визначення, дефініція, ясність, чітка чутність, sự định rõ, sự định nghĩa, lời định nghĩa sự định, diffiniad, darnodiad, for definition; vertaling, transferim, transmetim, ترجمة من لغة أجنبية للغة الأم, ترجمة, إفتتان, транслация, огъване, превод, предаване, поддаване, тълкуване, превеждане, 翻译, překlad, oversættelse, translatie, taajuusmuutos, translaatio, traduction, oersetting, Übersetzung, μετάφραση, תור'מ ות, תר'ום, "עתק", "עתק, fordítás, traduzione, 翻訳 , へい"ういどう, やくしょ, やくしゅつ, "うどく, ほ"やく, トランスレーション , やくじゅつ, ほ"やくしょ, 번역, tradukshon, tradução, translaţie, tãlmãcire, traducere, сдвиг, трансляция, перемещение, перевод, tumačenje, traducción, översättning, tercüme, процес перекладу, переклад, пояснення, переміщення, sự dịch, sự biến th nh sự giải thích, trosiad, for translation; Deens, danisht, danishte, لغة الدانمركية, نوع كعك, دانماركي, датски език, датски, Daniko, 丹麦语, dánský, dánština, danskur, danskt, tanskalainen, danois, Deensk, dänisch, δανικόσ, δανόσ, עו'ת שמרים, " י, dán, danska, Danmhairgis, danese, 덴마크, Danvargish, Danvargagh, danes, dinamarquês, danez, датский, danski, danski jezik, danés, dansk, danimarkalı, danimarka dili, датський, датська мова, tiếng Đan-mạch, for Danish; Nederlands, Hollands, holandez, هولندي, اللغة الهولندية, холандски, немски език, холандски език, холандците, немски, Olandes, 菏蘭語 , 荷兰语, holandský, nizozemský, hollandsk, hollendskt, hollantilainen, néerlandais, Nederlânsk, holländisch, ολλανδικόσ, ολλανδόσ, holandisht, "ול "י, holland, hollenskur, Ollainnis, olandese, 네덜란", Belanda, Ollanish, Germaanish, Tatimana, nederlandsk, ulandes, hulandes, holandês, neerlandés, olandez, nemţesc, limba olandezã, german, голландский, holanđanin, u škripcu, holandski, holandés, bakratongo, holländsk, ชาวเนเธอร์แลน"์, เกี่ยวกับเนเธอร์แลน"์, รรยา, alman, eş, flemenkçe, holandaca, hollanda, karı, hollandalı, hollandalılara özgü olan, Hollandali, hollanda'ya ait, голландська мова, голландський, ngôn ngữ khó hiểu, "b xã", for Dutch; Fins, finlandez, finlandishte, finlandisht, اللغة الفنلندية, فنلندية, فنلندي, фински език, фински, Pinlandino, 芬蘭語 , 芬兰语, finský, finskt, suomi, suomalainen, finnois, Finlandaise, finlandais, finnisch, φινλανδικόσ, פי י, finn, finnskur, finnska, finlandese, 핀란", Fynlannish, Fynlannagh, finlandês, finês, finlandezã, финский, Finisi, finski jezik, finski, finlandés, finés, finsk, fince, finlandiya'ya özgü, фінська мова, фінський, tiếng Phần-lan, for Finnish; Franse taal, Frans, franceze, francez, frëngjisht, frëng, frëngjishte, فرنسي, اللغة الفرنسية, الشعب الفرنسي, gall, френски език, френски, Pranses, 法國 , 法文 , 法語 , 法语, francouzština, francouzský, franskur, franskt, ranskalainen, français, Frânsk, französisch, γάλλοσ, γαλλικόσ, γαλλική γλώσσα, γαλλίδα, צרפתי, צרפתית, francia, Fraincis, francese, フレコン化 , フランス" , 仏文 , 仏 , ふつぶ", フレンチ , フランセ , ふつ, "랑스, Perancis, Ny Frangee, Mooinjey ny Frank, frances, franses, francês, francezii, francezã, franţuzesc, franţuzeşte, французский, Falani, francuski jezik, francuski, francuzi, francés, sí-Fulentji, fransk, franska, fransızca, Fransiz, fransızca ile ilgili, fransız, fransa ile ilgili, французька мова, французький, Ffrengig, isiFulentshi, for French; Grieks, Griek, الإغريقي, يوناني, اللغة اليونانية, Griegu, гръцки език, гръцки, грък, Griyego, 希臘語 , 希腊语, řecký, řeètina, řek, græker, grikst, kreikkalainen, grec, Gryk, Gryksk, Gryks, grieche, ελληνικόσ, 'Ελληνας, יו ית, יו י, görög, Grikki, greco, ギリシア語 , ギリシア", 그리스, Greagish, Greagagh, grego, grèc, greacã, греческий, Eleni, grk, grčki jezik, grčki, griego, grek, Yunanli, yunanlı, yunanca, yunan, Rumca, yunanistan'a ait, rum, грек, гречанка, грецька мова, грецький, kẻ cắp b gi gặp nhau, quân bạc bịp tôi không thể hiểu được điều đó thật l kỳ phùng địch thủ, người Hy-lạp tiếng Hy-lạp kẻ bịp bợm, kẻ lừa đảo, Groegwr, for Greek; Italianer, Italiaans, Italiaan, شخص إيطالي, اللغة الإيطالية, الإيطالي, إيطالي, Italianu, италиански език, италиански, италианец, Italyano, 意大利 , 意大利語 , 意大利语, italština, italský, ital, italiener, italienskt, italialainen, Italien, Italjaansk, italienisch, Ιταλός, italisht, איטלקי, איטלקית, olasz, Ítali, IodÚilis, italiano, 이탈리아, Iddaalish, Włoch, italianã, italienesc, italieneşte, italian, итальянский язык, итальянский, итальянец, Italia, italijanski, italijanski jezik, italijan, sí-Taliyáne, italienare, italiensk, italienska, เกี่ยวกับอิตาลี, ชาวอิตาลี, าษาอิตาลี, italyanca, italyan, італі"ць, італійська мова, італійський, італійка, for Italian; Spaans, Spaanse taal, spanjoll, اللغة الأسبانية, الأسبانية, أسباني, испански език, испански, espanyoles, Espanyol, 西班牙语, 西班牙文 , 西班牙語 , španìlský, španìlština, spanskt, espanjalainen, espagnol, Spaansk, spanisch, ισπανικά, ισπανικόσ, ισπανοί, karaiñe'êmegua, ספר"ית, ספר"י, spanyol, SpÚinnis, spagnolo, スペイン語 , スパイ罪 , スペイン", スパニッシュ , 스페인, Spaainagh, Spaainish, spañó, espanhol, espanhòl, spaniolesc, spanioleşte, spaniol, испанский, Sipaniolo, španski jezik, španski, español, spanska språk, spansk, ispanyollar, ispanyolca, ispanyol, іспанська мова, іспанський, for Spanish; 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