Copyright © Philip M. Parker, INSEAD. Terms of Use.

POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL

Specialty Definition: POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL

DomainDefinition

Health

Variation occurring within a species in the conformation of denatured DNA fragments. These single-stranded DNA fragments are allowed to partially renature in a way that prevents the formation of double-stranded DNA. The fragments are run on polyacrylamide gels under various conditions to detect subtle changes in migration due to altered secondary structure. The resulting bands will align themselves if the fragments are the same, but will misalign if any point mutations are present. SSCPs have been used in detecting mutations in various genes, such as oncogenes, tumor suppressor genes, and genes responsible for genetic diseases. (references)

Source: compiled by the editor from various references; see credits.

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Alternative Orthography: POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL


Hexadecimal (or equivalents, 770AD-1900s) (references)

50 4F 4C 59 4D 4F 52 50 48 49 53 4D 2C      53 49 4E 47 4C 45 2D 53 54 52 41 4E 44 45 44      43 4F 4E 46 4F 52 4D 41 54 49 4F 4E 41 4C

Leonardo da Vinci (1452-1519; backwards) (references)

        

Binary Code (1918-1938, probably earlier) (references)

01010000 01001111 01001100 01011001 01001101 01001111 01010010 01010000 01001000 01001001 01010011 01001101 00101100 00100000 01010011 01001001 01001110 01000111 01001100 01000101 00101101 01010011 01010100 01010010 01000001 01001110 01000100 01000101 01000100 00100000 01000011 01001111 01001110 01000110 01001111 01010010 01001101 01000001 01010100 01001001 01001111 01001110 01000001 01001100

HTML Code (1990) (references)

&#80 &#79 &#76 &#89 &#77 &#79 &#82 &#80 &#72 &#73 &#83 &#77 &#44 &#32 &#83 &#73 &#78 &#71 &#76 &#69 &#45 &#83 &#84 &#82 &#65 &#78 &#68 &#69 &#68 &#32 &#67 &#79 &#78 &#70 &#79 &#82 &#77 &#65 &#84 &#73 &#79 &#78 &#65 &#76

ISO 10646 (1991-1993) (references)

0050 004F 004C 0059 004D 004F 0052 0050 0048 0049 0053 004D 002C      0053 0049 004E 0047 004C 0045 002D 0053 0054 0052 0041 004E 0044 0045 0044      0043 004F 004E 0046 004F 0052 004D 0041 0054 0049 004F 004E 0041 004C

Encryption (beginner's substitution cypher): (references)

50494659474952504243534714253434841463915535452354838393823749484049524735544349483546

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INDEX

1. Orthography
2. Bibliography


  

Copyright © Philip M. Parker, INSEAD. Terms of Use.