Copyright © Philip M. Parker, INSEAD. Terms of Use.

Definition: Oncogene |
OncogeneNoun1. A gene that causes normal cells to change into cancerous tumor cells. Source: WordNet 1.7.1 Copyright © 2001 by Princeton University. All rights reserved. |
| Domain | Definitions |
Health | A gene that normally directs cell growth. If altered, an oncogene can promote or allow the uncontrolled growth of cancer. Alterations can be inherited or caused by an environmental exposure to carcinogens. (references) |
Medicine | Actually transforming retroviruses contain genes(oncogenes)that enable them to transform cells rapidly, this transformation leading to neoplastic growth. Source: European Union. (references) |
Source: compiled by the editor from various references; see credits. | |
(From Wikipedia, the free Encyclopedia)
Protooncogene
A protooncogene is a gene that is involved in signal transduction and execution of mitogenic signals, usually through its protein product. Upon activation, it (or its product) becomes a tumor inducing agent, an oncogene.Activation
The protooncogene can become an oncogene by a relatively small modification of its original function. There are two basic activation types:
Oncogene
Source: adapted by the editor from Wikipedia, the free encyclopedia under a copyleft GNU Free Documentation License (GFDL) from the article "Oncogene."
Synonym: OncogeneSynonym: transforming gene (n). (additional references) |
Crosswords: Oncogene |
| English words defined with "oncogene": proto-oncogene. (references) |
| Specialty definitions using "oncogene": Fusion Proteins, gag-onc ♦ Genes, erbA, Genes, erbB-2, Genes, fms ♦ hst-1 oncogene ♦ Ica oncogene ♦ Oncogene Proteins, Oncogene Proteins v-abl, Oncogene Proteins v-erbA, Oncogene Proteins v-erbB, Oncogene Proteins v-fos, Oncogene Proteins v-mos, Oncogene Proteins v-myb, Oncogene Proteins v-rel, Oncogene Proteins v-sis, Oncogene Proteins, Fusion, Oncogene Proteins, Viral ♦ ras Proteins ♦ sarc oncogene, Sarcoma Viruses, Simian, src-Family Kinases, STI571. (references) |
| Domain | Title |
Books |
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Source: compiled by the editor from various references; see credits. | |
| Thumbnail | Description & Credit | Thumbnail | Description & Credit |
This illustration with and without text, explains how a normal cell becomes a cancer cell. An oncogene in a normal cell appears to regulate and influence cell growth and division. When a cancer causing agent affects a cell's DNA and the oncogene is activated, a cancer cell develops. See artwork: GA-17. Credit: Jane Hurd (artist). | This graphic illustrates the stages of how a normal cell is converted to a cancer cell, when an oncogene becomes activated. Credit: Unknown photographer/artist. | ||
Shown is an electron micrograph of an oncogene in a cancer cell. Oncogenes have counterparts in normal cells called proto-oncogenes that control normal cell growth. Credit: Unknown photographer/artist. | A technique called in situ hybridization shows whether a gene is actively expressed in cells, and also provides clues to the gene's function. This technique has helped identify activated oncogenes in cancer cells, and their normal counterparts in normal cells, in many different species. In this photograph, a labeled DNA segment (a known oncogene) has been put into a mouse oocyte, a cell that develops into a mature egg cell. The labeled DNA has paired with (or hybridized to) multiple copies of RNA in the mouse oocyte. The presence of this RNA (shown here as black dots inside the nucleus of the immature cell) shows that the normal cellular counterpart of the oncogene is active, suggesting that it is critical for normal germ cell development. Expression of genes is manifested by the production of RNA transcripts within cells. Hybridization histochemistry (in situ hybridization) permits localization of these transcripts with cellular or greater resolution. Furthermore, the relative amounts of transcripts detected within different tissues or the same tissues under different states (e.g., physiological or developmental) may be quantified. See artwork: GA-17. Credit: Unknown photographer/artist. | ||
Source: pictures compiled by the editor from various references; see picture credits. | |||
| Subject | Topic | Quote |
Health | The presence of an oncogene is like having a gas pedal that is stuck to the floorboard, causing the cell to continually grow and divide. (references) | |
The proliferating cells then tend to acquire subsequent mutations involving a DNA repair gene, an oncogene, and several other tumor suppressor genes. (references) | ||
A number of oncogenes have already been found, and scientists continue to look for more. They are also working to identify specific events that can create oncogenes and to learn if there may be ways to prevent oncogenes from forming or to impair oncogene function in cancerous cells. (references) | ||
Source: compiled by the editor from ICON Group International, Inc.; see credits. | ||
| "Oncogene" is generally used as a noun (singular) -- approximately 95.00% of the time. "Oncogene" is used about 20 times out of a sample of 100 million words spoken or written in English. Its rank is based on over 700,000 words used in the English language. Some parts-of-speech are not covered due to the samples used by the British National Corpus. (note: percents less than one-hundredth of one percent have been omitted) |
| Parts of Speech | Percent | Usage per 100 Million Words | Rank in English |
| Noun (singular) | 95% | 19 | 80,337 |
| Noun (proper) | 5% | 1 | 339,140 |
| Total | 100.00% | 20 | N/A |
Source: compiled by the editor from several corpora; see credits.
Expressions using "oncogene": Ica oncogene ♦ Oncogene Protein gp140(v-fms) ♦ Oncogene Protein p21(ras) ♦ Oncogene Protein p55(v-myc) ♦ Oncogene Protein p65(gag-jun) ♦ Oncogene Protein pp60(v-src) ♦ Oncogene Proteins ♦ Oncogene Proteins v-abl ♦ Oncogene Proteins v-erbA ♦ Oncogene Proteins v-erbB ♦ Oncogene Proteins v-fos ♦ Oncogene Proteins v-mos ♦ Oncogene Proteins v-myb ♦ Oncogene Proteins v-rel ♦ Oncogene Proteins v-sis ♦ sarc oncogene. Additional references. | |
| Hypenated Usage | |
Ending with "oncogene": proto-oncogene. | |
Containing "oncogene": Proto-Oncogene Protein c-kit, Proto-Oncogene Protein c-met, Proto-Oncogene Protein p21(ras), Proto-Oncogene Protein pp60(c-src), Proto-Oncogene Proteins, Proto-Oncogene Proteins c-abl, Proto-Oncogene Proteins c-bcl-2, Proto-Oncogene Proteins c-fos, Proto-Oncogene Proteins c-jun, Proto-Oncogene Proteins c-mos, Proto-Oncogene Proteins c-myb, Proto-Oncogene Proteins c-myc, Proto-Oncogene Proteins c-raf, Proto-Oncogene Proteins c-rel, Proto-Oncogene Proteins c-sis. | |
| Source: compiled by the editor from various references; see credits. | |
| The following statistics estimate the number of searches per day across the major English-language search engines as identified by various trade publications. Hyperlinks lead to commercial use of the expression at Amazon.com. |
| Expression | Frequency per Day |
oncogene | 37 |
journal oncogene | 11 |
oncogene product research | 10 |
oncogene science | 7 |
oncogene proto | 4 |
oncogene research | 3 |
| Source: compiled by the editor from various references; see credits. | |
| Language | Translations for "oncogene"; alternative meanings/domain in parentheses. | ||||||||||||||||||||||
Danish | onkogen (carcinogenic, oncogenic, oncogenous, tumorigenic). (various references) | ||||||||||||||||||||||
Dutch | oncogen, onc gen, kankergen. (various references) | ||||||||||||||||||||||
Finnish | onkogeeni. (various references) | ||||||||||||||||||||||
French | oncogène (oncogenic). (various references) | ||||||||||||||||||||||
German | Onkogen (carcinogenic, oncogenic, oncogenous, tumorigenic), Krebsgen. (various references) | ||||||||||||||||||||||
Greek | ογκογονίδιο. (various references) | ||||||||||||||||||||||
Italian | oncogéne. (various references) | ||||||||||||||||||||||
Japanese Kanji | 癌遺伝子 , オロチン酸 (28.35g, angstrom, car, khaki, ombudsman, on, on air, on parade, on stage, on the air, on the air lamp, on the mark, on the rocks, on your mark, on-line, on-line real time system, on-line system, online-manual, only, only one, on-mike, on-off, on-side, on-site, Ontario, on-the-job training, onward, orotic acid, ounce, ovation). (various references) | ||||||||||||||||||||||
Japanese Katakana | が"いで"し, オンコジーン . (various references) | ||||||||||||||||||||||
Pig Latin | oncogeneay oncogene (carcinogenic, oncogenic, oncogenous, tumorigenic). (various references) oncogén. (various references) onkogen (carcinogenic, oncogenic, oncogenous, tumorigenic). (various references) | ||||||||||||||||||||||
Derivations | |
Words beginning with "oncogene": oncogenes, oncogeneses, oncogenesis. (additional references) | |
| Source: compiled by the editor, based on several corpora (additional references). | |
| # of Phoneme Matches | Pronunciation | Word(s) rhyming with "oncogene" (pronounced Ä"ngkōjē'n) |
| 3 | -j ē' n | hygiene. |
Source: compiled by the editor (additional references); see credits. | ||
Scrabble® Enable2K-Verified Anagrams | |
| Words within the letters "c-e-e-g-n-n-o-o" | |
-2 letters: congee, nonego. | |
-3 letters: cogon, conge, congo, cooee, nonce. | |
-4 letters: cone, conn, coon, gene, gone, goon, nene, neon, none, noon, ogee, once. | |
-5 letters: cee, cog, con, coo, ego, eng, eon, gee, gen, goo, nee, nog, noo, one. | |
| Words containing the letters "c-e-e-g-n-n-o-o" | |
+1 letter: oncogenes. | |
+2 letters: noncollege. | |
+3 letters: cognoscente, congenerous, monogenetic, noncolleges, noncoverage, oncogeneses, oncogenesis, ontogenetic. | |
+4 letters: cogeneration, decongestion, noncoverages. | |
+5 letters: cogenerations, congresswomen, decongestions, noncollegiate, organogenetic. | |
| Source: compiled by the editor from various references; see credits. SCRABBLE® is a registered trademark. All intellectual property rights in and to the game are owned in the U.S.A and Canada by Hasbro Inc., and throughout the rest of the world by J.W. Spear & Sons Limited of Maidenhead, Berkshire, England, a subsidiary of Mattel Inc. Mattel and Spear are not affiliated with Hasbro. | |
Hexadecimal (or equivalents, 770AD-1900s) (references)4F 6E 63 6F 67 65 6E 65 |
| Leonardo da Vinci (1452-1519; backwards) (references)
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| American Sign Language (origins from 1620-1817 in Italy and, especially, France) (references)
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| Semaphore (1791, in France) (references)
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| Braille (1829, in France) (references)
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Morse Code (1836) (references)--- -. -.-. --- --. . -. . |
| Dancing Men (Sir Arthur Conan Doyle, 1903) (references)
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Binary Code (1918-1938, probably earlier) (references)01001111 01101110 01100011 01101111 01100111 01100101 01101110 01100101 |
HTML Code (1990) (references)O n c o g e n e |
ISO 10646 (1991-1993) (references)004F 006E 0063 006F 0067 0065 006E 0065 |
| British Sign Language (Fingerspelling, BSL; 1992, British Deaf Association Dictionary of British Sign Language) (references)
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Encryption (beginner's substitution cypher): (references)4980698173718071 |
| 1. Definition 2. Synonyms 3. Crosswords 4. Usage: Commercial | 5. Images: Photo Album 6. Quotations: Non-fiction 7. Usage Frequency 8. Expressions | 9. Expressions: Internet 10. Translations: Modern 11. Derivations 12. Rhymes | 13. Anagrams 14. Orthography 15. Bibliography |
Copyright © Philip M. Parker, INSEAD. Terms of Use.
| Note to the press & webmasters - this dictionary can be linked, indexed, or referred to using the following non-English expressions: woordeboek, fjalor, معجم, قاموس, diccionariu, речник, diccionari, diksyonario, diksinario, 字典, gérlyver, slovník, ordbog, woordenboek, shimiyuc p'anca, orðabók, orðbók, dictionnaire, wurdboek, wörterbuch, λεξικό, אוצר מילים, szótár, uqausiit tukingit, dizionario, 字引 , じい, じびき, じて", ディクショナリー , じり", じしょ, '"かい, ディクショナリ , 사 , dizionari, recnik, fockleyr, dikshonario, słownik, dicionário, dicţionar, dicziunari, словарь, lolomi fefiloi, foclair, abardair, faclair, briathrachan, pukuntau, leksikon, rečnik, vocabbulariu, diccionario, sí-chazamagâma, ordbok, lexikon, พจนานุกรม, sözlük, ansiklopedik sözlük, словник, довідник, có tính chất sách vở, geirlyfr, geiriadur, for dictionary; definisie, qartësi, përcaktim, saktësi, الوضوحية في الشيء, حد, تحديد, تعريف, التحديد, الإيضاحية, яснота, сила, очертания, дефиниция, 定義 , 定义, definice, deskriptordefinition, definitie, määritelmä, définition, ορισμός, "'"ר", "'בל", meghatározás, definíció, definizione, 確定 , ディーゼル電気車 , デ'ドロ酢酸 , デフィニション , ディフィニション , ていぎ, かくてい, 의, geyrid, meenaghey, keeayllaght, baght, definishon, definição, definiţie, determinare, definire, определение, definicija, definición, definition, açıklama, belirleme, belirtme, kesinleştirme, tanım, tarif, seçiklik, tanımlama, чіткість, тлумачення, виразність, визначення, дефініція, ясність, чітка чутність, sự định rõ, sự định nghĩa, lời định nghĩa sự định, diffiniad, darnodiad, for definition; vertaling, transferim, transmetim, ترجمة من لغة أجنبية للغة الأم, ترجمة, إفتتان, транслация, огъване, превод, предаване, поддаване, тълкуване, превеждане, 翻译, překlad, oversættelse, translatie, taajuusmuutos, translaatio, traduction, oersetting, Übersetzung, μετάφραση, תור'מ ות, תר'ום, "עתק", "עתק, fordítás, traduzione, 翻訳 , へい"ういどう, やくしょ, やくしゅつ, "うどく, ほ"やく, トランスレーション , やくじゅつ, ほ"やくしょ, 번역, tradukshon, tradução, translaţie, tãlmãcire, traducere, сдвиг, трансляция, перемещение, перевод, tumačenje, traducción, översättning, tercüme, процес перекладу, переклад, пояснення, переміщення, sự dịch, sự biến th nh sự giải thích, trosiad, for translation; Deens, danisht, danishte, لغة الدانمركية, نوع كعك, دانماركي, датски език, датски, Daniko, 丹麦语, dánský, dánština, danskur, danskt, tanskalainen, danois, Deensk, dänisch, δανικόσ, δανόσ, עו'ת שמרים, " י, dán, danska, Danmhairgis, danese, 덴마크, Danvargish, Danvargagh, danes, dinamarquês, danez, датский, danski, danski jezik, danés, dansk, danimarkalı, danimarka dili, датський, датська мова, tiếng Đan-mạch, for Danish; Nederlands, Hollands, holandez, هولندي, اللغة الهولندية, холандски, немски език, холандски език, холандците, немски, Olandes, 菏蘭語 , 荷兰语, holandský, nizozemský, hollandsk, hollendskt, hollantilainen, néerlandais, Nederlânsk, holländisch, ολλανδικόσ, ολλανδόσ, holandisht, "ול "י, holland, hollenskur, Ollainnis, olandese, 네덜란", Belanda, Ollanish, Germaanish, Tatimana, nederlandsk, ulandes, hulandes, holandês, neerlandés, olandez, nemţesc, limba olandezã, german, голландский, holanđanin, u škripcu, holandski, holandés, bakratongo, holländsk, ชาวเนเธอร์แลน"์, เกี่ยวกับเนเธอร์แลน"์, รรยา, alman, eş, flemenkçe, holandaca, hollanda, karı, hollandalı, hollandalılara özgü olan, Hollandali, hollanda'ya ait, голландська мова, голландський, ngôn ngữ khó hiểu, "b xã", for Dutch; Fins, finlandez, finlandishte, finlandisht, اللغة الفنلندية, فنلندية, فنلندي, фински език, фински, Pinlandino, 芬蘭語 , 芬兰语, finský, finskt, suomi, suomalainen, finnois, Finlandaise, finlandais, finnisch, φινλανδικόσ, פי י, finn, finnskur, finnska, finlandese, 핀란", Fynlannish, Fynlannagh, finlandês, finês, finlandezã, финский, Finisi, finski jezik, finski, finlandés, finés, finsk, fince, finlandiya'ya özgü, фінська мова, фінський, tiếng Phần-lan, for Finnish; Franse taal, Frans, franceze, francez, frëngjisht, frëng, frëngjishte, فرنسي, اللغة الفرنسية, الشعب الفرنسي, gall, френски език, френски, Pranses, 法國 , 法文 , 法語 , 法语, francouzština, francouzský, franskur, franskt, ranskalainen, français, Frânsk, französisch, γάλλοσ, γαλλικόσ, γαλλική γλώσσα, γαλλίδα, צרפתי, צרפתית, francia, Fraincis, francese, フレコン化 , フランス" , 仏文 , 仏 , ふつぶ", フレンチ , フランセ , ふつ, "랑스, Perancis, Ny Frangee, Mooinjey ny Frank, frances, franses, francês, francezii, francezã, franţuzesc, franţuzeşte, французский, Falani, francuski jezik, francuski, francuzi, francés, sí-Fulentji, fransk, franska, fransızca, Fransiz, fransızca ile ilgili, fransız, fransa ile ilgili, французька мова, французький, Ffrengig, isiFulentshi, for French; Duits, Duitser, Duitse taal, Germaan, gjerman, ضرب من الرقص, جرماني, المانية, الماني, اللغة الألمانية, роден, германски, немски език, немски, немец, готически, германец, 德語 , 德语, 德文 , 德國 , nìmecký, nìmec, tysker, Duitse, týskur, týskt, týskari, saksalainen, Allemand, Dútsk, Deutsche, Deutsch, "ερμανός, gjermanisht, 'רמ י, 'רמ ית, német, þjóðverji, þýskur, GearmÚnach, GearmÚinis, tedesco, ジプシー音楽 , ジャーマン , 독일, todesch, Germaanagh, Garmane, Germaanish, Carmane, aleman, Niemiec, niemiecki, alemão, alemand, neamţ, немецкий, Siamani, germanski, alemán, Tudesku, Doysri, mjeremani, mdachi, sí-Jalimáne, tysk, เยอรมัน, าษาเยอรมัน, Alman, німкеня, німецький, німець, $sisters german$ chị em ruột, $cousin german$ anh chị em con chú bác ruột, sister, Almaenwr, isiJalimane, iliJalimane, iJalimane, for German; Grieks, Griek, الإغريقي, يوناني, اللغة اليونانية, Griegu, гръцки език, гръцки, грък, Griyego, 希臘語 , 希腊语, řecký, řeètina, řek, græker, grikst, kreikkalainen, grec, Gryk, Gryksk, Gryks, grieche, ελληνικόσ, 'Ελληνας, יו ית, יו י, görög, Grikki, greco, ギリシア語 , ギリシア", 그리스, Greagish, Greagagh, grego, grèc, greacã, греческий, Eleni, grk, grčki jezik, grčki, griego, grek, Yunanli, yunanlı, yunanca, yunan, Rumca, yunanistan'a ait, rum, грек, гречанка, грецька мова, грецький, kẻ cắp b gi gặp nhau, quân bạc bịp tôi không thể hiểu được điều đó thật l kỳ phùng địch thủ, người Hy-lạp tiếng Hy-lạp kẻ bịp bợm, kẻ lừa đảo, Groegwr, for Greek; Italianer, Italiaans, Italiaan, شخص إيطالي, اللغة الإيطالية, الإيطالي, إيطالي, Italianu, италиански език, италиански, италианец, Italyano, 意大利 , 意大利語 , 意大利语, italština, italský, ital, italiener, italienskt, italialainen, Italien, Italjaansk, italienisch, Ιταλός, italisht, איטלקי, איטלקית, olasz, Ítali, IodÚilis, italiano, 이탈리아, Iddaalish, Włoch, italianã, italienesc, italieneşte, italian, итальянский язык, итальянский, итальянец, Italia, italijanski, italijanski jezik, italijan, sí-Taliyáne, italienare, italiensk, italienska, เกี่ยวกับอิตาลี, ชาวอิตาลี, าษาอิตาลี, italyanca, italyan, італі"ць, італійська мова, італійський, італійка, for Italian; Portugees, portugez, portugalisht, اللغة البرتغالية, البرتغالية, البرتغالي, португалски език, португалски, португалец, Potuges, 葡萄牙语, 葡萄牙人 , 葡萄牙語 , portugalský, portugiser, portugisiskt, portugalilainen, portugais, Portugeesk, portugiesisch, πορτογάλοσ, ορτογάλος, portugál, Portaingéilis, portoghese, ポルトガル語 , ポルトガル", 포르투갈, Portiugish, Portiugagh, portugues, Portugalczyk, português, portughez, португальский, portugalski jezik, portugalski, portugalac, portugués, Mreno, si-Putúkezi, portugis, portekiz, Portekízlí, portekizli, portekizce, португальська мова, португальський, португалець, người B"-đ o-nha tiếng B"-đ o-nha, for Portuguese; Spaans, Spaanse taal, spanjoll, اللغة الأسبانية, الأسبانية, أسباني, испански език, испански, espanyoles, Espanyol, 西班牙语, 西班牙文 , 西班牙語 , španìlský, španìlština, spanskt, espanjalainen, espagnol, Spaansk, spanisch, ισπανικά, ισπανικόσ, ισπανοί, karaiñe'êmegua, ספר"ית, ספר"י, spanyol, SpÚinnis, spagnolo, スペイン語 , スパイ罪 , スペイン", スパニッシュ , 스페인, Spaainagh, Spaainish, spañó, espanhol, espanhòl, spaniolesc, spanioleşte, spaniol, испанский, Sipaniolo, španski jezik, španski, español, spanska språk, spansk, ispanyollar, ispanyolca, ispanyol, іспанська мова, іспанський, for Spanish; Sweeds, suedez, اللغة السويدية, Suecu, шведски език, шведски, швед, Swedis, 瑞典語 , 瑞典语, švédský, švédština, Zweeds, svenskt, ruotsalainen, suédois, Sweedsk, schwedisch, σουηδικόσ, σουηδικά, svéd, sænskur, Sualainnis, svedese, スウェーデン語 , スウェーデン", 스웨덴, Soolynish, Soolynagh, suèc, шведский, švedski jezik, švedski, sueco, svensk, เกี่ยวกับคน าษาและวั'นธรรมของประเทศสวีเ"น, isveççe, isveç dili, isveç, Ísveçlí, шведська мова, шведський, người Thuỵ điển tiếng Thuỵ điển, for Swedish; |