Copyright © Philip M. Parker, INSEAD. Terms of Use.

Nicotine

Definition: Nicotine

Nicotine

Noun

1. An alkaloid poison that occurs in tobacco; used in medicine and as an insecticide.

Source: WordNet 1.7.1 Copyright © 2001 by Princeton University. All rights reserved.
 

Date "nicotine" was first used in popular English literature: sometime before 1870. (references)

Etymology: Nicotine \Nic"o*tine\, noun. [French expression nicotine. See Nicotian.]. (Websters 1913)



Specialty Definitions: Nicotine

DomainDefinitions

Food & Agriculture

Nicotinic alkaloids. Source: European Union. (references)

Health

Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke. (references)

Literature

Nicotine (3 syl.) is so named from Jean Nicot, Lord of Villemain, who purchased some tobacco at Lisbon in 1560, introduced it into France, and had the honour of fixing his name on the plant. Our word tobacco is from the Indian tabaco (the tube used by the Indians for inhaling the smoke). Source: Brewer's Dictionary.

Source: compiled by the editor from various references; see credits.

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Specialty Definition: Nicotine

(From Wikipedia, the free Encyclopedia)

Nicotine is an organic compound, an alkaloid found naturally throughout the tobacco plant, with a high concentration in the leaves. It constitutes circa 5% of the plant by weight. It is a potent nerve poison and is included in many insecticides. In lower concentrations, the substance is a stimulant and is one of the main factors leading to the addictiveness of tobacco smoking. In addition to the tobacco plant, nicotine is also found in lower quantities in other members of the Solanaceae (nightshade) family, which includes tomato, potato, eggplant (aubergine), and green pepper.

Chemical properties

The chemical formula of nicotine is C10H14N2 and the structure is

This structure is reflected in the official name 3-(2-(N-methylpyrrolidinyl))pyridine.

Nicotine is water soluble and can be extracted by leaving the cut tobacco in a glass of water for 12 hours.

The CAS number of nicotine is 54-11-5.

Effects on the body

In small doses nicotine has a stimulating effect, increasing activity, alertness and memory. Repeat users report a pleasant relaxing effect. It also increases the heart rate and blood pressure and reduces the appetite. In large doses it may cause vomiting and nausea. The LD50 is 50 mg/kg for rats and 3 mg/kg for mice.

Repeat users of nicotine become physically addicted. A report by US Surgeon General C. Everett Koop released on May 16, 1988 stated that the addictive properties of nicotine are similar to those of heroin and cocaine. Withdrawal symptoms include irritability, headaches and anxiety. These symptoms may last for months or years, although they peak at around 48-72 hours.

Although the amount of nicotine inhaled with tobacco smoke is quite small (most of the substance is destroyed by the heat) it is still sufficient to cause addiction. The amount of nicotine absorbed by the body from smoking depends on many factors, including the type of tobacco, whether the smoke is inhaled, and whether a filter is used.

As nicotine enters the body, it quickly gets distributed through the bloodstream and can cross the blood-brain barrier. On average it takes about seven seconds for the substance to reach the brain. It acts on the nicotinic acetylcholine receptors. In small concentrations it increases the activity of these receptors, among other things leading to an increased flow of adrenaline, a stimulating hormone. The release of adrenaline causes an increase in heart rate, blood pressure and respiration, as well as higher glucose levels in the blood. In high doses, nicotine blocks the nicotinic acetylcholine receptor, which is the reason for its toxicity and its effectiveness as an insecticide.

In addition, nicotine increases dopamine levels in the reward circuits of the brain by repressing the production of monoamine oxidase (MAO), an enzyme responsible for breaking down dopamine. Thus it generates feelings of pleasure. This reaction is similar to that caused by cocaine and heroin, and is another reason for the addictive nature of nicotine: people keep smoking to sustain high dopamine levels.

It has been noted that the majority of schizophrenics smoke tobacco. Estimates for the number of schizophrenics that smoke range from 75% to 90%. It is argued that the increased level of smoking in schizophrenia may be due to a desire to self-medicate with nicotine.

History and name

Nicotine is named after the tobacco plant Nicotiana tabacum which in turn is named after Jean Nicot, who sent tobacco seeds from Portugal to Paris in 1550 and promoted its medicinal use. It was first isolated in 1828; its molecular formula was established in 1843 and it was first synthesized in 1904.

Source: adapted by the editor from Wikipedia, the free encyclopedia under a copyleft GNU Free Documentation License (GFDL) from the article "Nicotine."

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Synonyms within Context: Nicotine

ContextSynonyms within Context (source: adapted from Roget's Thesaurus).

Bane

Poison, toxin; teratogen; leaven, virus venom; arsenic; antimony, tartar emetic; strychnine, nicotine; miasma, miasm, mephitis, malaria, azote, sewer gas; pest.

Pungency

Nicotine, tobacco, snuff, quid, smoke; segar; cigar, cigarette; weed; fragrant weed, Indian weed; Cavendish, fid, negro head, old soldier, rappee, stogy.

Source: adapted from Roget's Thesaurus.

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Crosswords: Nicotine

English words defined with "nicotine": IsonicotineNicotidine, nicotine addiction, nicotine poisoning, Nicotinicvasoconstrictive, vasoconstrictor. (references)
Specialty definitions using "nicotine": Botanical Pesticide, Botanical pesticidescotininenickin', nicotine amblyopiaOligohydramniosReceptors, Cholinergic, Receptors, Muscarinic, Receptors, Nicotinicstraight-edgeUar. (references)
Etymologies containing "nicotine": Isonicotine. (references)
Non-English Usage: "Nicotine" is also a word in the following language with the English translation in parentheses.

French (nicotine).

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Modern Usage: Nicotine

DomainUsage

Screenplays

A delivery device for Nicotine. (The Insider; writing credit: Eric Roth)

Okay, I think it's time to change someone's nicotine patch. (Friends; writing credit: Jörn O. Jensen; Birger Larsen)

She proposes that nicotine is a gift from the gods, and if men may benefit from its soothing qualities, why then may women not also? (Topsy-Turvy; writing credit: Mike Leigh)

It won't be the nicotine that kills you, Mr. Bond. (You Only Live Twice; writing credit: Roald Dahl)

Lyrics

I've been living on coffee and nicotine ("Everyday is a Winding Road"; performing artist: Sheryl Crow)

Movie/TV Titles

In the Nicotine (1961)

The Smoke Fairy Princess Nicotine; or (1909)

Nicotine Dreams (1998)

Source: compiled by the editor from various references; see credits.

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Commercial Usage: Nicotine

DomainTitle

References

  • The 2002 Official Patient's Sourcebook on Nicotine Dependence (reference)

  • The World Market for Nicotine and Its Salts: A 2004 Global Trade Perspective (reference)

    (more reference examples)

  

Books

  • Advances in Nicotine Research (reference)

  • Escape from Nicotine Country: How to Stop Smoking Painlessly (reference)

  • If Only I Could Quit: Recovering from Nicotine Addiction (reference)

  • My Lady Nicotine (reference)

  • Nicotine Addiction: Principles and Management (reference)

    (more book examples)

  

Music

Source: compiled by the editor from various references; see credits.

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Image Slideshow: Nicotine

Computer Images:
Nicotine

More images...

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Photo Album: Nicotine

ThumbnailDescription & CreditThumbnailDescription & Credit

"We don't want to inhale nicotine" says the child on this Soviet poster. / WHO p.Credit: National Library of Medicine; photo by Novosti..

Tar, Carbon Monoxide and Nicotine Yields of Cigarettes : Smokers die younger!.Credit: National Library of Medicine.

Source: compiled by the editor from various references; see credits.

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Familiar Quotations: Nicotine

AuthorQuotation

Carry Nation

Men are nicotine soaked, beer besmirched, whiskey greased, red-eyed devils.

Source: compiled by the editor from various references.

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Non-Fiction Usage: Nicotine

SubjectTopicQuote

Health

Yes, nicotine is addictive. (references)

Chronic exposure to nicotine results in addiction. (references)

Nicotine can act as both a stimulant and a sedative. (references)

Source: compiled by the editor from ICON Group International, Inc.; see credits.

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Usage Frequency: Nicotine

"Nicotine" is generally used as a noun (singular) -- approximately 100.00% of the time. "Nicotine" is used about 183 times out of a sample of 100 million words spoken or written in English. Its rank is based on over 700,000 words used in the English language. Some parts-of-speech are not covered due to the samples used by the British National Corpus. (note: percents less than one-hundredth of one percent have been omitted)
Parts of SpeechPercentUsage per
100 Million Words
Rank in English
Noun (singular)100%18322,794

Source: compiled by the editor from several corpora; see credits.

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Expression: Nicotine

Expressions using "nicotine": nicotine addiction nicotine amblyopia nicotine fit nicotine poisoning. Additional references.

Hyphenated Usage

Beginning with "nicotine": nicotine-dosed, nicotine-laden, nicotine-stained, nicotine-yellowed.

Ending with "nicotine": anti-nicotine.

Source: compiled by the editor from various references; see credits.

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Frequency of Internet Keywords: Nicotine

The following statistics estimate the number of searches per day across the major English-language search engines as identified by various trade publications. Hyperlinks lead to commercial use of the expression at Amazon.com.
 
ExpressionFrequency
per Day

nicotine

608

nicotine patch

166

nicotine withdrawal

132

nicotine addiction

107

nicotine gum

76

nicotine anonymous

52

nicotine withdrawl

46

nicotine free cigarette

45

nicotine withdrawal symptom

45

effects of nicotine

37

nicotine test

29

blood test nicotine

26

nicotine inhaler

24

nicotine testing

24

nicotine poisoning

18

alzheimers nicotine

17

nicotine withdrawl symptom

16

nicotine in blood

15

nicotine fact

15

nicotine urine test

12
Source: compiled by the editor from various references; see credits.

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Modern Translations: Nicotine

Language Translations for "nicotine"; alternative meanings/domain in parentheses.

Albanian

  

nikotinë. (various references)

   

Arabic 

  

‏نيكوتين مادة في التبغ. (various references)

   

Bulgarian 

  

никотин. (various references)

   

Chinese 

  

尼古丁 (Nicotinic). (various references)

   

Czech

  

nikotin. (various references)

   

Danish

  

nikotin. (various references)

   

Dutch

  

nicotine. (various references)

   

Farsi 

  

نیکوتین . (various references)

   

Finnish

  

nikotiini. (various references)

   

French

  

nicotine. (various references)

   

German

  

Nikotin. (various references)

   

Greek 

  

νικοτίνη. (various references)

   

Hebrew 

  

יקוטין. (various references)

   

Hungarian

  

nikotin. (various references)

   

Indonesian

  

nikotin. (various references)

   

Italian

  

nicotina. (various references)

   

Japanese Kanji 

  

(fat, lard, resin, sleep in one's eyes, tallow). (various references)

   

Japanese Katakana 

  

ニコチン , やに (resin, sleep in one's eyes). (various references)

   

Korean 

  

니"틴. (various references)

   

Manx

  

nicoteen. (various references)

   

Pig Latin

  

icotinenay

   

Portuguese

  

nicotina (nicotinism), fumante (smoker). (various references)

   

Romanian

  

nicotinã. (various references)

   

Russian 

  

никотин. (various references)

   

Serbo-Croatian

  

nikotin. (various references)

   

Spanish

  

nicotina. (various references)

   

Swedish

  

nikotin (nicotian). (various references)

   

Thai

  

สารนิโคตินในยาสูบหรือบุหรี่. (various references)

   

Turkish

  

nikotin. (various references)

   

Ukranian 

  

нікотин. (various references)

   

Vietnamese 

  

nicôtin. (various references)

Source: compiled by the editor from various translation references.

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Derivations & Misspellings: Nicotine

Derivations

Words beginning with "nicotine": nicotines. (additional references)


Misspellings

"Nicotine" is suggested in spellcheckers for the following: Hikotani, Kikoine, Narodnie, Niccolin, Niccolino, niciciana, nicoise, nicotania, nicoteen, nicotene, nicotin, nicotinate, Nicotinell, Nikitina, Niodini, nycodenz. (additional references)

Source: compiled by the editor, based on several corpora (additional references).

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Rhyming with "Nicotine"

# of Phoneme MatchesPronunciationWord(s) rhyming with "nicotine" (pronounced ni"kutē'n)
4-u t ē' ncarotene, guillotine.
3-t ē' nargentine, elephantine, Holstein, libertine, mangosteen, protein, quarantine.

Source: compiled by the editor (additional references); see credits.

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Anagrams: Nicotine

Scrabble® Enable2K-Verified Anagrams

Words within the letters "c-e-i-i-n-n-o-t"

-1 letter: coniine, nicotin.

-2 letters: conine, incite, intine, intone, nocent, noetic, notice.

-3 letters: cento, conin, conte, inion, ionic, niton, nonce, nonet, ontic, tenon, tonic, tonne.

-4 letters: cent, cine, cion, cite, coin, cone, coni, conn, cote, etic, icon, inti, into, neon, nice, nine, nite, none, note, once, otic, tine, tone.

-5 letters: con, cot, eon, ice, inn, ion, net, nit, not, one, ten, tic, tie, tin, toe, ton.

 Words containing the letters "c-e-i-i-n-n-o-t"
 

+1 letter: inception, incondite, infection, injection, nicotines.

 

+2 letters: bentonitic, centillion, coincident, conceiting, concertini, extinction, inceptions, infections, inflection, injections, inspection, interionic, noncitizen, nonmimetic, omnificent, omniscient, sectioning.

 

+3 letters: benediction, centillions, cointerring, coinventing, conditioned, conditioner, declination, decondition, discontinue, enunciation, extinctions, fibronectin, incinerator, inconscient, incontinent, indirection, inflections, inspections, interaction, internuncio, necrotizing, noncitizens, nondiabetic, nontheistic, pectination, phonetician, recognition, recondition, reinfection, reinjection.

 

+4 letters: antieconomic, antientropic, antiviolence, benedictions, canonicities, coincidental, coincidently, concertizing, concinnities, concretizing, conditioners, confidential, congeniality, connectivity, containerise, containerize, continuative, continuities, declinations, deconditions, denunciation, deracination, discontinued, discontinues, disinfection, emancipation, enantiomeric, enunciations, fibronectins, incineration, incinerators, inclinometer, inconsistent, incontinence, incontinency, inconvenient, indirections, indiscretion, indoctrinate, indomethacin, inflectional, insurrection, intellection, interactions, interception, intercession, interdiction, interjection, interlocking, internuncios, interoceanic, intersection, introjecting, introjection, isoantigenic, nicotinamide, nonaddictive, nonantigenic, noncertified, noncognitive, nondiabetics, nondirective, nonidentical, noninductive, noninfective, nonrealistic, nonscientist, omnisciently, oncogenicity, pectinations, phoneticians, precognition, precondition, preinduction, recognitions, reconditions, reconvicting, reconviction, reinfections, reinjections, reinspection, renunciation, reunionistic, sanctimonies, somnifacient.

 

+5 letters: amniocentesis, antiobscenity, antirecession, antirejection, autoinfection, beneficiation, circumvention, clotheslining, complimenting, concentricity, conditionable, conscientious, consideration, consistencies, containerised, containerises, containerized, containerizes, containership, contaminative, contingencies, counterfiring, countermining, declinational, deconditioned, densification, denticulation, denunciations, deracinations, disconcerting, disconnecting, disconnection, discontenting, disinfections, emancipations, fianchettoing, fictioneering, functionaries, immunogenetic, incarceration, incinerations, inclinometers, incongruities, inconsecutive, inconsiderate, inconsistence, inconsistency, inconstancies, incontinences, incontinently, inconvertible, inconvertibly, indiscretions, indoctrinated, indoctrinates, indomethacins, insurrections, intellections, interactional, intercalation, interceptions, intercessions, intercolonial, intercropping, intercrossing, interdictions, interjections, intersections, introjections, introspecting, introspection, mechanization, micronutrient, miscegenation, misconception, misconnecting, misconnection, misfunctioned, necessitation, nicotinamides, nitroglycerin, noncreativity, noninfectious, nonscientific, nonscientists, nonspecialist, postinfection, postinjection, precautioning, precognitions, preconditions, preconviction, preinductions, recombination, reconditioned, reconnoitring, reconvictions, recrimination, rediscounting, reincarnation, reinoculating, reinoculation, reinspections, reintroducing, renunciations, reunification, revaccination, somnifacients, spectinomycin, triamcinolone, unconditioned, undoctrinaire.

Source: compiled by the editor from various references; see credits.

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Alternative Orthography: Nicotine


Hexadecimal (or equivalents, 770AD-1900s) (references)

4E 69 63 6F 74 69 6E 65

Leonardo da Vinci (1452-1519; backwards) (references)

American Sign Language (origins from 1620-1817 in Italy and, especially, France) (references)

=

Semaphore (1791, in France) (references)

Braille (1829, in France) (references)

Morse Code (1836) (references)

-.    ..    -.-.    ---    -    ..    -.    .

Dancing Men (Sir Arthur Conan Doyle, 1903) (references)

Binary Code (1918-1938, probably earlier) (references)

01001110 01101001 01100011 01101111 01110100 01101001 01101110 01100101

HTML Code (1990) (references)

&#78 &#105 &#99 &#111 &#116 &#105 &#110 &#101

ISO 10646 (1991-1993) (references)

004E 0069 0063 006F 0074 0069 006E 0065

British Sign Language (Fingerspelling, BSL; 1992, British Deaf Association Dictionary of British Sign Language) (references)

Encryption (beginner's substitution cypher): (references)

4875698186758071

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INDEX

1. Definition
2. Crosswords
3. Usage: Modern
4. Usage: Commercial
5. Images: Slideshow
6. Images: Photo Album
7. Quotations: Familiar
8. Quotations: Non-fiction
9. Usage Frequency
10. Expressions
11. Expressions: Internet
12. Translations: Modern
13. Derivations
14. Rhymes
15. Anagrams
16. Orthography
17. Bibliography


  

Copyright © Philip M. Parker, INSEAD. Terms of Use.