Copyright © Philip M. Parker, INSEAD. Terms of Use.
Definition: Haemophilia |
HaemophiliaNoun1. Congenital tendency to uncontrolled bleeding; usually affects males and is transmitted from mother to son. Source: WordNet 1.7.1 Copyright © 2001 by Princeton University. All rights reserved. |
| Domain | Definitions |
Health | A haemorrhagic diathesis occurring in two main forms : (1) haemophilia A (classic haemophilia, factor VIII deficiency), an X-linked disorder due to deficiency of coagulation factor VIII; (2) haemophilia B (factor IX deficiency, Christmas disease), also X-linked, due to deficiency of coagulation factor IX. Both forms are determined by a mutant gene near the telomere of the long arm of the X chromosome (Xq), but a different loci, and are characterized by subcutaneous and intramuscular haemorrhages; bleeding from the mouth, gums, lips, and tongue; haematuria; and haemarthroses. (references) |
Source: compiled by the editor from various references; see credits. | |
(From Wikipedia, the free Encyclopedia)
Haemophilia can be controlled quite successfully today by regular injections of a given clotting factor like Factor VIII.
The reason that haemophilia mostly affects males is that it is sex-linked. Women have two X-chromosomes whereas men have one X and one Y. It does not matter if there is a defect in a woman's X-chromosome, as the equivalent allele in her other chromosome would express itself and she would not have the illness. However the Y-chromosome in men has no gene for factors VIII or IX. If the recessive gene responsible for blood clotting in a man's X-chromosome is deficient there is no equivalent on the Y-chromosome, so the deficient gene is not masked by the dominant allele and he will develop the illness.
This means also that although women can be carriers of the illness, if men have the gene they also have the illness. It is possible, though rare, for a woman to have the illness, if her father is a haemophiliac and her mother a carrier, or if there is a defect in one of her X chromosomes and she inherits a haemophilia gene from one of her parents. This situation is far more common today than it once was, as improved treatment for haemophilia means that more men survive to adulthood and become parents. Adult women with haemophilia menstruate periodically, so they must take clotting factor to survive.
Haemophilia figured prominently in the history of European royalty. Queen Victoria passed the mutation to her son Leopold and, through daughters, to the royal families of Spain and Russia. For this reason it was once popularly called "the royal disease." See Grigori Rasputin for Alexis. Of her descendant royalties, the German and British houses did not receive this disorder.
The diseases were passed on to:
Treatment
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See also
Source: adapted by the editor from Wikipedia, the free encyclopedia under a copyleft GNU Free Documentation License (GFDL) from the article "Haemophilia."
Synonyms: HaemophiliaSynonyms: bleeder's disease (n), hemophilia (n). (additional references) |
Crosswords: Haemophilia |
| English words defined with "haemophilia": classical haemophilia ♦ haemophilia A, haemophilia B. (references) |
| Domain | Title |
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Source: compiled by the editor from various references; see credits. | |
| "Haemophilia" is generally used as a noun (singular) -- approximately 95.35% of the time. "Haemophilia" is used about 43 times out of a sample of 100 million words spoken or written in English. Its rank is based on over 700,000 words used in the English language. Some parts-of-speech are not covered due to the samples used by the British National Corpus. (note: percents less than one-hundredth of one percent have been omitted) |
| Parts of Speech | Percent | Usage per 100 Million Words | Rank in English |
| Noun (singular) | 95.35% | 41 | 53,521 |
| Noun (proper) | 4.65% | 2 | 245,945 |
| Total | 100.00% | 43 | N/A |
Source: compiled by the editor from several corpora; see credits.
Expressions using "haemophilia": classical haemophilia ♦ haemophilia A ♦ haemophilia B. Additional references. | |
| Source: compiled by the editor from various references; see credits. |
| The following statistics estimate the number of searches per day across the major English-language search engines as identified by various trade publications. Hyperlinks lead to commercial use of the expression at Amazon.com. |
| Expression | Frequency per Day |
haemophilia | 136 |
astrazeneca haemophilia | 21 |
haemophilia symptom | 2 |
| Source: compiled by the editor from various references; see credits. | |
| Language | Translations for "haemophilia"; alternative meanings/domain in parentheses. | |
Albanian | hemofili (hemophilia). (various references) | |
Arabic | الهموفيليا مرض بالدم (hemophilia), الناعورية نزعة النزف الدموى (hemophilia). (various references) | |
Bulgarian | хемофилия. (various references) | |
Chinese | 血友病 (hemophilia). (various references) | |
Czech | hemofilie, dìdièná krvácivost. (various references) | |
Danish | haemofili (hereditary haemophilia), hæmofili. (various references) | |
Dutch | hemofilie (bleeder's disease, hemophilia, hereditary haemophilia). (various references) | |
French | hémophilie (hereditary haemophilia). (various references) | |
German | Haemorrhaphilia (hereditary haemophilia), Haemophilia (bleeder's disease, hemophilia, hereditary haemophilia), Hämophilie (bleeder's disease, hemophilia, hereditary haemophilia), Hämophilie, Bluterkrankheit (bleeder's disease, hemophilia, hereditary haemophilia). (various references) | |
Greek | αιμοφιλία (bleeder's disease, hemophilia, hereditary haemophilia). (various references) | |
Hebrew | "ממת. (various references) | |
Hungarian | vérzékenység (hemophilia). (various references) | |
Italian | emofilia (hemophilia, hereditary haemophilia). (various references) | |
Japanese Kanji | 血友病 . (various references) | |
Japanese Katakana | けつゆうびょう. (various references) | |
Manx | ym-roie folley. (various references) | |
Pig Latin | aemophiliahay.(various references) | |
Portuguese | hemofilia (bleeder's disease, haemophiliac, hemophilia, hemophiliac, hereditary haemophilia). (various references) | |
Russian | гемофилия (hemophilia). (various references) | |
Serbo-Croatian | hemofilija (hemophilia). (various references) | |
Spanish | hemofilia (bleeder's disease, hemophilia, hereditary haemophilia). (various references) | |
Swedish | hemofili (hemophilia), blödarsjuka. (various references) | |
Thai | ส าวะที่เลือ"ไหลไม่หยุ" (hemophilia). (various references) | |
Turkish | hemofili (hemophila), kan hastalığı. (various references) | |
Ukranian | гемофілія (hemophilia). (various references) | |
| Source: compiled by the editor from various translation references. | ||
Scrabble® Enable2K-Verified Anagrams | |
| Words within the letters "a-a-e-h-h-i-i-l-m-o-p" | |
-1 letter: hemophilia. | |
-3 letters: hemiolia. | |
-4 letters: aphelia, hemiola, omphali. | |
-5 letters: haemal, hiemal, impala, impale, lamiae, lipoma, phloem. | |
| Source: compiled by the editor from various references; see credits. SCRABBLE® is a registered trademark. All intellectual property rights in and to the game are owned in the U.S.A and Canada by Hasbro Inc., and throughout the rest of the world by J.W. Spear & Sons Limited of Maidenhead, Berkshire, England, a subsidiary of Mattel Inc. Mattel and Spear are not affiliated with Hasbro. | |
Hexadecimal (or equivalents, 770AD-1900s) (references)48 61 65 6D 6F 70 68 69 6C 69 61 |
| Leonardo da Vinci (1452-1519; backwards) (references)
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| American Sign Language (origins from 1620-1817 in Italy and, especially, France) (references)
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| Semaphore (1791, in France) (references)
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| Braille (1829, in France) (references)
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Morse Code (1836) (references).... .- . -- --- .--. .... .. .-.. .. .- |
| Dancing Men (Sir Arthur Conan Doyle, 1903) (references)
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Binary Code (1918-1938, probably earlier) (references)01001000 01100001 01100101 01101101 01101111 01110000 01101000 01101001 01101100 01101001 01100001 |
HTML Code (1990) (references)H a e m o p h i l i a |
ISO 10646 (1991-1993) (references)0048 0061 0065 006D 006F 0070 0068 0069 006C 0069 0061 |
| British Sign Language (Fingerspelling, BSL; 1992, British Deaf Association Dictionary of British Sign Language) (references)
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Encryption (beginner's substitution cypher): (references)4267717981827475787567 |
| 1. Definition 2. Synonyms 3. Crosswords 4. Usage: Commercial | 5. Usage Frequency 6. Expressions 7. Expressions: Internet 8. Translations: Modern | 9. Anagrams 10. Orthography 11. Bibliography |
Copyright © Philip M. Parker, INSEAD. Terms of Use.
