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FUSION PROTEINS, BCR-ABL

Specialty Definition: FUSION PROTEINS, BCR-ABL

DomainDefinition

Health

Translation products of a fusion mRNA derived from the breakpoint cluster region (bcr) gene and a cellular abl (c-abl) gene translocated to chromosome 22. The p210(bcr-abl) fusion protein is found in patients with chronic myelogenous leukemia. The p190(bcr-abl) fusion protein is found in patients with acute lymphocytic leukemia. The activation of human c-abl by chromosomal translocation is essentially the same as the activation of murine c-abl by viral translocation in Abelson murine leukemia virus. (references)

Source: compiled by the editor from various references; see credits.

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Alternative Orthography: FUSION PROTEINS, BCR-ABL


Hexadecimal (or equivalents, 770AD-1900s) (references)

46 55 53 49 4F 4E      50 52 4F 54 45 49 4E 53 2C      42 43 52 2D 41 42 4C

Leonardo da Vinci (1452-1519; backwards) (references)

        

Binary Code (1918-1938, probably earlier) (references)

01000110 01010101 01010011 01001001 01001111 01001110 00100000 01010000 01010010 01001111 01010100 01000101 01001001 01001110 01010011 00101100 00100000 01000010 01000011 01010010 00101101 01000001 01000010 01001100

HTML Code (1990) (references)

&#70 &#85 &#83 &#73 &#79 &#78 &#32 &#80 &#82 &#79 &#84 &#69 &#73 &#78 &#83 &#44 &#32 &#66 &#67 &#82 &#45 &#65 &#66 &#76

ISO 10646 (1991-1993) (references)

0046 0055 0053 0049 004F 004E      0050 0052 004F 0054 0045 0049 004E 0053 002C      0042 0043 0052 002D 0041 0042 004C

Encryption (beginner's substitution cypher): (references)

4055534349482505249543943485314236375215353646

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INDEX

1. Orthography
2. Bibliography


  

Copyright © Philip M. Parker, INSEAD. Terms of Use.