Fibrin

Definition: Fibrin

Fibrin

Noun

1. A white insoluble fibrous protein formed by the action of thrombin on fibrinogen when blood clots; it forms a network that traps red cells and platelets.

Etymology: Fibrin \Fi"brin\, noun. [Compare to the French expression fibrine. See Fiber.]. (Websters 1913)

Specialty Definitions: Fibrin

Domain	Definitions
Health	A protein derived from fibrinogen in the presence of thrombin, which forms part of the blood clot. (references)
Source: compiled by the editor from various references; see credits.

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Specialty Definition: Fibrin

(From Wikipedia, the free Encyclopedia)

Fibrin is the protein responsible for the clotting of blood. It is a fibrillar protein that spontaneously polymerises to form a mesh that covers a wound.

Fibrin is made from fibrinogen, a soluble plasma protein that is produced by the liver. Processes in the coagulation cascade activate the enzyme thrombin, which is responsible for converting fibrinogen into fibrin. Fibrin can then polymerise and form a clot.

Fibrin generation

The liver produces fibrinogen, which normally has a concentration between 1.8 - 4.0 g/L in blood plasma. In its natural form, fibrinogen is useful in forming bridges between platelets, by binding to their GpIIb/IIIa membrane proteins; though fibrinogen's major use is as a precursor to fibrin.

Fibrinogen is a dimer (it is composed of two identical units). Each of these units has an alpha, a beta, and a gamma chain. On the alpha and beta chains, there is a small peptide sequence (called a fibrinopeptide). It is these small peptides that prevent fibrinogen spontaneously forming polymers with itself.

Processes in the coagulation cascade activate a protease enzyme known as thrombin (or activated Factor II). Thrombin cleaves the fibrinopeptides off the alpha and beta chains of fibrinogen, converting it to fibrin.

The central units of fibrin are now free to react with the terminal units of the other molecules (as the fibrinopeptides blocking this reaction have been removed).

The active molecules of fibrin stack up on each other, usually incorporating (by trapping) aggregrates of platelets. The fibrin molecules are later cross-linked (by factor XIII) covalently, to form a stable haemostatic plug, thus effectively stopping bleeding.

Source: adapted by the editor from Wikipedia, the free encyclopedia under a copyleft GNU Free Documentation License (GFDL) from the article "Fibrin."

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Crosswords: Fibrin

English words defined with "fibrin": Blood serum ♦ Defibrinate, Defibrination ♦ factor I, factor XIII, Fibrin factors, Fibrin ferment, fibrinase, Fibrination, fibrinogen, Fibrinogenous, fibrinolysin, fibrinolysis, fibrinopeptide, Fibrinoplastic, Fibrinoplastin, fibrinous ♦ Gluten fibrin ♦ Hyperinosis, Hypinosis ♦ Peptotoxine, plasmin, Proteid ♦ Zymome. (references)

Specialty definitions using "fibrin": Antiplasmin ♦ Clot Retraction ♦ Fibrin Fibrinogen Degradation Products, Fibrin Tissue Adhesive, Fibrinogens, Abnormal, fibrinolytic, Fibrinopeptide A ♦ Intracranial Thrombosis ♦ Pancreatic Elastase, Partial Thromboplastin Time, Periodic Acid-Schiff Reaction, Protein-Glutamine gamma-Glutamyltransferase ♦ Shwartzman Phenomenon ♦ Thrombelastography, Thrombin Time ♦ Urinary Calculi. (references)

Non-English Usage: "Fibrin" is also a word in the following languages with English translations in parentheses.

Czech (fibrin), Danish (fibrin), German (fibrin), Serbo-Croatian (fibrin), Swedish (fibrin), Turkish (fibrin), Vietnamese (fibrin).

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Commercial Usage: Fibrin

Domain	Title
Books	Fibrin Sealant in Operative Medicine (Otorhinolaryngology, Vol 1) (reference) Fibrin Sealing In Surgical and Nonsurgical (reference) Fibrinogen: Fibrin Formation and Fibrinolysis: Proceedings, Workshop on Fibrinogen, April 2-3, 1985, London England (reference) Molecular biology of fibrinogen and fibrin (reference) (more book examples)
Source: compiled by the editor from various references; see credits.

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Photo Album: Fibrin

Thumbnail	Description & Credit
	Left ventricle of heart has been opened to show mitral valve fibrin vegetations due to infection with Haemophilus parainfluenzae. Autopsy.Credit: CDC.
Source: compiled by the editor from various references; see credits.

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Non-Fiction Usage: Fibrin

Subject	Topic	Quote
Health		Focal hyalin membranes are observed, as well as extensive intraalveolar edema and fibrin. (references)
		The researchers fixed the grafts in place with a glue based on a blood-clotting factor called fibrin. (references)
		Higher power magnification showing the antraalveolar exudate composed mainly of polymorphonuclear leukocytes, red blood cells, and fibrin. (references)
Source: compiled by the editor from ICON Group International, Inc.; see credits.

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Usage Frequency: Fibrin

"Fibrin" is generally used as a noun (singular) -- approximately 100.00% of the time. "Fibrin" is used about 31 times out of a sample of 100 million words spoken or written in English. Its rank is based on over 700,000 words used in the English language. Some parts-of-speech are not covered due to the samples used by the British National Corpus. (note: percents less than one-hundredth of one percent have been omitted)

Parts of Speech	Percent	Usage per 100 Million Words	Rank in English
Noun (singular)	100%	31	62,296

Source: compiled by the editor from several corpora; see credits.

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Expressions: Fibrin

Expressions using "fibrin": Fibrin factors ♦ Fibrin ferment ♦ Fibrin Fibrinogen Degradation Products ♦ Fibrin Foam ♦ Fibrin Tissue Adhesive ♦ Gluten fibrin ♦ vegetable fibrin. Additional references.
Hyphenated Usage
	Beginning with "fibrin": fibrin-affinity, fibrin-dissolving, fibrin-fibrinogen, fibrin-rich, fibrin-selective, fibrin-selectivity, fibrin-specificity.
Source: compiled by the editor from various references; see credits.

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Frequency of Internet Keywords: Fibrin

The following statistics estimate the number of searches per day across the major English-language search engines as identified by various trade publications. Hyperlinks lead to commercial use of the expression at Amazon.com.

Expression	Frequency per Day
fibrin	21
fibrin glue	10
fibrin sealant	3
anal fibrin fistula glue	2
fibrin bandage	2
fibrin degradation product	2
Source: compiled by the editor from various references; see credits.

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Modern Translations: Fibrin

Language		Translations for "fibrin"; alternative meanings/domain in parentheses.
Albanian		fibrinë. (various references)

Arabic		‏الليفين. (various references)

Bulgarian		фибрин. (various references)

Chinese		纤维蛋白. (various references)

Czech		fibrin. (various references)

Danish		fibrin. (various references)

Dutch		fibrine. (various references)

Finnish		fibriini, nauta (bovine), fibriini, ihminen (human). (various references)

French		fibrine. (various references)

German		Fibrin. (various references)

Greek		λευκή ινώδησ ουσία. (various references)

Hebrew		ליפין, פיבר�". (various references)

Hungarian		rostanyag (fiber, fibre). (various references)

Italian		fibrina. (various references)

Pig Latin		ibrinfay

Portuguese		fibrina, humana (human), fibrina, bovina (bovine), fibrina (fibroid), fibrilação (fibrillation, flutter, forming). (various references)

Russian		фибрин. (various references)

Serbo-Croatian		fibrin. (various references)

Spanish		fibrina. (various references)

Swedish		fibrin, humant (human), fibrin, bovint (bovine), fibrin. (various references)

Thai		โปรตีนซึ่งทำให้โลหิตแข็งตัว. (various references)

Turkish		fibrin, lifli protein. (various references)

Ukranian		фібрин, клейковина (gluten). (various references)

Vietnamese		fibrin, tơ huyết. (various references)
Source: compiled by the editor from various translation references.

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Derivations & Misspellings: Fibrin

Derivations
	Words beginning with "fibrin": fibrinogen, fibrinogens, fibrinoid, fibrinoids, fibrinolyses, fibrinolysin, fibrinolysins, fibrinolysis, fibrinolytic, fibrinopeptide, fibrinopeptides, fibrins. (additional references)
	Words containing "fibrin": defibrinate, defibrinated, defibrinates, defibrinating, defibrination, defibrinations. (additional references)
Misspellings
	"Fibrin" is suggested in spellcheckers for the following: Fabri, Fabron, febris, febru, Febry, ferin, Fibi, fibra, Fibrenyl, fibrinoid, fibrom, Fikri, Fiorano, Fiorini, Firby, firen, ibrin. (additional references)
Source: compiled by the editor, based on several corpora (additional references).

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Rhyming with "Fibrin"

# of Phoneme Matches	Pronunciation	Word(s) rhyming with "fibrin" (pronounced fī"brun)
3	-r u n	apron, aspirin, Baron, barren, brethren, Buran, cauldron, Chevron, children, citron, doctrine, foreign, garron, giron, grandchildren, heron, intron, Marron, matron, octahedron, patron, perron, Philodendron, polyhedron, rhododendron, saffron, schoolchildren, siren, sovereign, sovran, squadron, stepchildren, tetrahedron, Warren.
Source: compiled by the editor (additional references); see credits.

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Anagrams: Fibrin

Scrabble® Enable2K-Verified Anagrams
	Words within the letters "b-f-i-i-n-r"
	-2 letters: brin, firn.
	-3 letters: bin, fib, fin, fir, nib, rib, rif, rin.
	-4 letters: bi, if, in.
	Words containing the letters "b-f-i-i-n-r"
	+1 letter: fibrins, fibroin.
	+2 letters: briefing, fibroins.
	+3 letters: briefings, fibrinoid, fribbling.
	+4 letters: backfiring, befringing, brutifying, debriefing, fiberizing, fibrinogen, fibrinoids, forbidding, furbishing, inferrible, interfiber, ribbonfish, riboflavin, tenebrific, verbifying.
	+5 letters: befingering, befriending, beneficiary, bifurcating, bifurcation, debriefings, defibrinate, fabricating, fabrication, fibrinogens, fibronectin, fimbriation, fireballing, firebombing, frostbiting, infrangible, infrangibly, neurofibril, riboflavins.
Source: compiled by the editor from various references; see credits. SCRABBLE® is a registered trademark. All intellectual property rights in and to the game are owned in the U.S.A and Canada by Hasbro Inc., and throughout the rest of the world by J.W. Spear & Sons Limited of Maidenhead, Berkshire, England, a subsidiary of Mattel Inc. Mattel and Spear are not affiliated with Hasbro.