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Cytotoxic

Definition: Cytotoxic

Cytotoxic

Adjective

1. Of or relating to substances that are toxic to cells.

Source: WordNet 1.7.1 Copyright © 2001 by Princeton University. All rights reserved.
 


Specialty Definition: Cytotoxic

DomainDefinition

Health

Cell-killing. (references)

Medicine

Causing cell death ; a chemical compound, drug, pollutant or radioactive material that damages the cells of living organisms. Source: European Union. (references)

Source: compiled by the editor from various references; see credits.

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Specialty Definition: Cytotoxic T cell

(From Wikipedia, the free Encyclopedia)

A cytotoxic (or TC) T cell is a T cell (a type of white blood cell) which has on its surface antigen receptors that can bind to fragments of antigens displayed by the Class I MHC molecules of infected somatic cells.

Once bound to an antigen, TC cells release the protein perforin, which forms pores in the target cell's plasma membrane; this causes ions and water to flow into the target cell, making it expand and eventually lyse.

Most TC cells have present on the cell surface the protein CD8, which is attracted to portions of the Class I MHC molecule. This affinity keeps the TC cell and the target cell bound closely together during antigen-specific activation. TC cells with CD8 surface protein are called CD8+ T cells.

See also:

Source: adapted by the editor from Wikipedia, the free encyclopedia under a copyleft GNU Free Documentation License (GFDL) from the article "Cytotoxic T cell."

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Crosswords: Cytotoxic

Specialty definitions using "cytotoxic": 4-Chloromercuribenzenesulfonatealpha 1-Antichymotrypsin, Antigens, CD8, Antigens, LyBiological Response ModifiersCD8 antigen, CD8 glycoprotein, CD8 molecule, CD8 protein, CD8-Positive T-Lymphocytes, Cobra Venoms, cytotoxic T cell, cytotoxic T cells, cytotoxic T lymphocyte, Cytotoxicity Tests, Immunologic, Cytotoxicity, ImmunologicDianhydrogalactitol, Dihydroxytryptamines, Drug Screening Assays, AntitumorEosine I BluishGlaucarubinimmune-response, immunological reaction, Immunosuppressive Agents, immunotoxin, Interleukin-18LymphotoxinMacrophage-Activating Factors, microinjection, micro-injection, Misonidazole, Monocytes, Activated KillerOndansetronPhosphoramide Mustards, Polyvinylpyridine N-Oxide, Prostaglandin D2RadioimmunotherapyStreptonigrinT8 antigen, T8 glycoprotein, T8 molecule, T8 protein, T-cytotoxic cell, T-Lymphocyte Subsets, T-Lymphocytes, T-Lymphocytes, Cytotoxic, Tumor Lysis SyndromeViper Venoms. (references)

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Commercial Usage: Cytotoxic

DomainTitle

Books

  • Cytotoxic Cells: Basic Mechanisms and Medical Applications (reference)

  • Cytotoxic Conjugates (Medical Intelligence Unit) (reference)

  • Cytotoxic drugs in the treatment of cancer (reference)

  • Cytotoxic Effector Mechanisms (reference)

  • Cytotoxic Mediators of Inflammation and Host Defense (Progress in Allergy, Vol 40) (reference)

    (more book examples)

Source: compiled by the editor from various references; see credits.

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Non-Fiction Usage: Cytotoxic

SubjectTopicQuote

Health

Treatment may include cortisone or cytotoxic drugs. (references)

With the cooperation of a helper T cell, the cytotoxic T cell matures. (references)

After reducing protein in the urine with prednisone, the doctor may prescribe the cytotoxic agent for a while. (references)

Source: compiled by the editor from ICON Group International, Inc.; see credits.

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Usage Frequency: Cytotoxic

"Cytotoxic" is generally used as an adjective (general or positive) -- approximately 100.00% of the time. "Cytotoxic" is used about 31 times out of a sample of 100 million words spoken or written in English. Its rank is based on over 700,000 words used in the English language. Some parts-of-speech are not covered due to the samples used by the British National Corpus. (note: percents less than one-hundredth of one percent have been omitted)
Parts of SpeechPercentUsage per
100 Million Words
Rank in English
Adjective (general or positive)100%3162,296

Source: compiled by the editor from several corpora; see credits.

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Expressions: Cytotoxic

Expressions using "cytotoxic": cytotoxic chemotherapy cytotoxic drug cytotoxic effect cytotoxic T cell cytotoxic T cells cytotoxic T lymphocyte. Additional references.

Hypenated Usage

Ending with "cytotoxic": non-cytotoxic, T-cytotoxic.

Source: compiled by the editor from various references; see credits.

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Frequency of Internet Keywords: Cytotoxic

The following statistics estimate the number of searches per day across the major English-language search engines as identified by various trade publications. Hyperlinks lead to commercial use of the expression at Amazon.com.
 
ExpressionFrequency
per Day

cytotoxic

22

agent cytotoxic

5

cytotoxic drug

4

chemotherapy cytotoxic

3

cytotoxic substance

3

cytotoxic definition

2

cytotoxic t cell

2

cytotoxic drug stability

2

cytotoxic response

2

agent cytotoxic handling

2
Source: compiled by the editor from various references; see credits.

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Modern Translation: Cytotoxic

Language Translations for "cytotoxic"; alternative meanings/domain in parentheses.

Chinese 

  

细胞' . (various references)

   

Danish

  

cytotoksisk. (various references)

   

Dutch

  

cytotoxisch. (various references)

   

Finnish

  

sytotoksinen, soluja tuhoava, soluille myrkyllinen. (various references)

   

French

  

cytotoxique. (various references)

   

German

  

zytotoxisch. (various references)

   

Greek 

  

κυτταροτοξικός,κυτοτοξικός, κυτταροτοξικό /ός. (various references)

   

Italian

  

citotossico. (various references)

   

Pig Latin

  

ytotoxiccay

   

Portuguese

  

citotóxico, citotóxico. (various references)

   

Spanish

  

citotóxico. (various references)

   

Swedish

  

cytotoxisk. (various references)

Source: compiled by the editor from various translation references.

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Derivations: Cytotoxic

Derivations

Words beginning with "cytotoxic": cytotoxicities, cytotoxicity. (additional references)

Source: compiled by the editor, based on several corpora (additional references).

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Anagrams: Cytotoxic

Scrabble® Enable2K-Verified Anagrams

Words within the letters "c-c-i-o-o-t-t-x-y"

-1 letter: oxytocic.

-3 letters: tictoc.

-4 letters: toxic.

-5 letters: city, coco, coot, otic, otto, toit, toot, toyo.

 Words containing the letters "c-c-i-o-o-t-t-x-y"
 

+1 letter: exocytotic.

 

+3 letters: cytotoxicity.

 

+4 letters: cytotaxonomic.

 

+5 letters: cytotoxicities.

Source: compiled by the editor from various references; see credits.

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INDEX

1. Definition
2. Crosswords
3. Usage: Commercial
4. Quotations: Non-fiction
5. Usage Frequency
6. Expressions
7. Expressions: Internet
8. Translations: Modern
9. Derivations
10. Anagrams
11. Bibliography


  

Copyright © Philip M. Parker, INSEAD. Terms of Use.