CORONARY PRIMARY PREVENTION TRIAL

Medicine

Source: compiled by the editor from various references; see credits.

Health

One of these studies, the Lipid Research Clinics Coronary Primary Prevention Trial, showed a statistically significant 19 percent reduction in the combined rate of fatal and nonfatal coronary heart disease in association with a 9 percent decrease in blood cholesterol level. (references)

In the Framingham Heart Study, the Lipid Research Clinics (LRC) Mortality Followup Study, the LRC Coronary Primary Prevention Trial, and the Multiple Risk Factor Intervention Trial quantitative analysis of the data was consistent with a 2 to 3 percent decrease in CHD risk for each 1 mg/dL increase in HDL-C level, after adjustment to control for other risk factors. (references)

Since this study did not measure HDL levels, no conclusions could be drawn with regard to HDL. In the Lipid Research Clinics' Coronary Primary Prevention Trial, the overall decline in CHD risk was 19 percent, 2 percent of which was attributable to an increase in HDL that was correlated with a 2 percent decline in CHD risk, and the benefit was greatest in those with a baseline HDL > 50 mg/dL. It should be noted that significant correlations were demonstrated also between lowering of LDL cholesterol and coronary risk. In the Helsinki Heart Study, a mean 12 percent rise in HDL-C and an 11 percent fall in LDL-C were both correlated with a 34 percent decline in CHD events. (references)

Source: compiled by the editor from ICON Group International, Inc.; see credits.

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