COMMON VARIABLE IMMUNODEFICIENCY

Health

Source: compiled by the editor from various references; see credits.

Health

Common Variable Immunodeficiency (CVID) is the name given to a group of disorders characterized by low levels of gammaglobulins and too few IgA antibodies. (references)

For example, a young infant suffering from diarrhea, pneumonia, and thrush, and exhibiting "failure to thrive," may well have SCID. A 4-year-old with swollen lymph glands, skin problems, pneumonia, and bone infections may have Chronic Granulomatous Disease (CGD). A 10-year old with sinus and respiratory infections, an enlarged spleen, and signs of autoimmune problems is apt to have Common Variable Immunodeficiency. (references)

Early studies based on small sample sizes have indicated that almost any desired blood level of IgG can be obtained by use of intravenous immunoglobulin and that infection rates are reduced by use of IVIG as compared with IM IG. IVIG has been shown to ameliorate chronic sinopulmonary disease that developed in patients on long-term IM IG. There is a suggestion that chronic enterovirus meningoencephalitis in patients with X-linked agammaglobulinemia may be less frequent in those receiving prophylactic IVIG as compared with historical data in which IM IG was used. Hence, IVIG has become the current standard in clinical practice for replacement therapy of patients with primary immunodeficiencies (e.g., X-linked agammaglobulinemia and common variable immunodeficiency and immunoglobulin subclass deficiency in which deficiencies of antibody production to common pathogens can be demonstrated). (references)

Source: compiled by the editor from ICON Group International, Inc.; see credits.

Danish

common variable immunodeficiency. (various references)

Dutch

algemene variabele immuundeficiëntie. (various references)

French

déficit immunitaire variable commun. (various references)

German

allgemeine variable Immunmangelkrankheit. (various references)

Greek 

κοινή ποικίλλουσα ανοσοανεπάρκεια. (various references)

Italian

immunodeficienza variabile comune. (various references)

Pig Latin

ommoncay ariablevay immunodeficiencyay

Portuguese

imunodeficiência variável comum. (various references)

Spanish

inmunodeficiencia variable común. (various references)