BASEMENT MEMBRANE

Definition: BASEMENT MEMBRANE

BASEMENT MEMBRANE

1. (Anat.), a delicate membrane composed of a single layer of flat cells, forming the substratum upon which, in many organs, the epithelioid cells are disposed.

Source: Webster's Revised Unabridged Dictionary (1913)
 

Health

Source: compiled by the editor from various references; see credits.

Crosswords: BASEMENT MEMBRANE

Books

• Extracellular Matrix in the Kidney: 6th International Symposium on Basement Membrane, Shizuoka, May 29-June 1, 1993 (Contributions to Nephrology, Vo) (reference)

• The Glomerular Basement Membrane (reference)

• Basement Membrane Components and Their Receptors in Organogenesis (Comprehensive Summaries of Uppsala Dissertations, 498) (reference)

  (more book examples)

Source: compiled by the editor from various references; see credits.

This illustration with and without text, titled "How Cancer Spreads" explains the process of metastasis. Once metastatic cells are attached to the basement membrane (a physical barrier that seperates tissue components), they break through with the help of an enzyme called type IV collagenase. Cancer cells then move through the blood stream enabling them to spread to other parts of the body. A secondary tumor may form at another site in the body. See artwork: GA-17.Credit: Jane Hurd (artist).

The metastatic colony is the end result of a complicated multistep process. The tumor cells from a primary tumor invade local tissue and gain access to the venous circulation (intravasation). Circulating tumor cells, singly or in clumps, are transported to target organs where they lodge in the capillary bed. Thus arrested, these tumor cells penetrate the endothelial cell lining and the underlining basement membrane to exit the circulation (extravasation). They then grow as a metastatic colony, a development that requires new blood vessels (neovascularization). To complete this multistep process, the tumor cells must overcome the host's defenses.Credit: Unknown photographer/artist.

(a) cross-section of infiltrating ductal carcinoma of the breast with blood vessels at the periphery of tumor. Magnification x100. (b) cross-section of infiltrating ductal carcinoma of the breast with vessels at the periphery of tumor. Magnification x200. (c) cross section of infiltrating ductal carcinoma of the breast with a small foci of breast cancer cells in which cd34 antibody has stained blood vessels and basement membrane. Magnification x100. (d) cross-section of infiltrating ductal carcinoma of breast shows intense blood vessel proliferation in stromal tissue adjacent to the malignant tissue. Magnification x200.Credit: Unknown photographer/artist.

Source: compiled by the editor from various references; see credits.

Health

Less frequently, the irregular basement membrane will form concentric lines in the central cornea that resemble small fingerprints. (references)

Bowman's Layer - Lying directly below the basement membrane of the epithelium is a transparent sheet of tissue known as Bowman's layer. (references)

The part of the epithelium that serves as the foundation on which the epithelial cells anchor and organize themselves is called the basement membrane. (references)

Source: compiled by the editor from ICON Group International, Inc.; see credits.

Expression using "BASEMENT MEMBRANE": Anti-Glomerular Basement Membrane Disease. Additional references.

Danish

basalmembran (basilar membrane, Henle elastic membrane, Henle fenestrated membrane). (various references)

Dutch

basaalmembraan, membrana basalis, grondvlies. (various references)

French

vitrée, membrane basale. (various references)

German

Basishaeutchen, Basilemma, Basalmembran, Basalhuelle, Lamina densa, Grundhaeutchen, Grenzhaeutchen, Glashaut (cellophane, viscose film, zona pellucida, zona radiata, zona striata). (various references)

Greek 

βασική ή θεμέλια μεμβράνη. (various references)

Italian

basilemma, membranella reticolare, membrana ialina, membrana basale. (various references)

Pig Latin

asementbay embranemay

Portuguese

membrana basal. (various references)

Spanish

membrana basal. (various references)

Misspellings

"BASEMENT MEMBRANE" is suggested in spellcheckers for the following: basementmembrane. (additional references)

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