Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof

Invention: Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof

Year	Description
1994	Invention patented by Robert J. Suhadolnik and Wolfgang Pfleiderer on November 2nd, 1994. Abstract: Viral infection is inhibited in mammals by administration of metabolically stable, non-toxic 2', 5'-oligoadenylate (2-5A) derivatives that have a dual therapeutic effect. The compounds activate the intracellular latent 2-5A dependent endoribonuclease RNase L and also inhibit the action of viral DNA polymerases. Conjugates of the 2-5A derivatives for therapeutic delivery are also described.
Source: selected by the editor from original sources.