DNA and polypeptide for tumor-associated antigen CO-029

  

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DNA and polypeptide for tumor-associated antigen CO-029

Invention: DNA and polypeptide for tumor-associated antigen CO-029

Year    Description
1990Invention patented by Alban J. Linnenbach, Hilary Koprowski, and Stanislaw Szala on August 30th, 1990. Abstract: The human tumor-associated antigen CO-029 is a monoclonal antibody-defined, 27-34 kDa cell surface glycoprotein. A full-length cDNA clone for CO-029 is described. When transiently expressed in COS cells, the cDNA clone directs the synthesis of an antigen reactive with monoclonal antibody CO-029 in mixed hemadsorption and immunoblot assays. Sequence analysis reveals that CO-029 belongs to a family of cell surface antigens which includes the melanoma-associated antigen ME491, the leukocyte cell surface antigen CD37, and the Sm23 antigen of the parasitic helminth Schistosoma mansoni.
Source: selected by the editor from original sources.

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