DI (1R)-(-)camphosulfonic acid) salt, preparation thereof and use thereof

Year	Description
1995	Invention patented by Alfred P. Spada, Cynthia A. Fink, Michael R. Myers, Laurence W. Reilly, and Benoit J. Vanasse on June 6th, 1995. Abstract: This invention relates to di›(1 R)-(-)-camphosulfonic acid) salt of ›1S-›1.alpha.,2.beta.,3.beta.,4.alpha.,(S)!!-4-›7-››2-(3-chloro-2-thienyl)-1-ethylethyl!amino!3 H-imidazo›4,5-b!pyridin-3-yl!-N-ethyl-2,3-dihydroxycyclopentanecarboxamide, and a process for preparing the compound, comprising reacting a reaction mixture of (-)-1.beta.-N-ethyl-2.alpha.,3.alpha.-isopropylidenedioxy-4.beta.-›3-amino-4-›2-(5-chloro-2-thienyl)-(1R)-1-ethylethyl!amino-2-pyridyl!aminocyclopentanecarboxamide and formamidine acetate, and then treating the reaction mixture with (1 R)-(-)-10-camphorsulfonic acid. The salt is useful in purifying ›1 S-›1.alpha.,2.beta.,3.beta.,4.alpha.,(S)!!-4-›7-››2-(3-chloro-2-thienyl)-1-ethylethyl!amino!-3 H-imidazo›4,5-b!pyridin-3-yl!-N-ethyl-2,3-dihydroxycyclopentanecarboxamide which possesses adenosine agonist activity and is useful as an anti-hypertensive, cardioprotective, anti-ischemic, and antilipolytic agent.
Source: selected by the editor from original sources.

Invention: DI (1R)-(-)camphosulfonic acid) salt, preparation thereof and use thereof