Azaaspartic acid analogs as interleukin-1.beta. converting enzyme inhibitors

  

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Azaaspartic acid analogs as interleukin-1.beta. converting enzyme inhibitors

Invention: Azaaspartic acid analogs as interleukin-1.beta. converting enzyme inhibitors

Year    Description
1994Invention patented by Roland E. Dolle and Todd L. Graybill on August 1st, 1994. Abstract: Disclosed are compounds, compositions and methods for inhibiting interleukinprotease activity. The compounds, .alpha.-substituted acetamides a ##STR1## wherein: R.sub.2 =H or alkyl; R.sup.3 =halo, O(CO).sub.0-1 aryl, OPOR.sup.4 R.sup.5 ; ##STR2## where R.sup.4 and R.sup.5 =aryl; R.sup.6 =H, aryl or aralkyl; R.sup.7 =independently selected from R.sup.6, CF.sub.3 and CF.sub.2 CF.sub.3 ; R.sup.1 =R.sup.6 -CO, heteroaryl-CO, heteroaralkyl-CO and amino acid.
Source: selected by the editor from original sources.

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