Ataxia-telangiectasia gene and its genomic organization

Year	Description
1996	Invention patented by Yosef Shiloh on April 7th, 1996. Abstract: A purified and isolated gene, designated ATM, mutations of which cause ataxia-telangiectasia and its genomic organization is disclosed. Methods and a kit for the detection of carriers of mutations of the ATM gene are provided by analysis of nucleic acids isolated from patients including in situ hybridization, Northern blotting and reverse transcriptase--polymerase chain reaction, Southern blotting, single strand conformational polymorphism, restriction endonuclease fingerprinting (REF), PCR amplification and DNA-chip analysis.
1998	Invention patented by Yosef Shiloh on February 1st, 1998. Abstract: A purified and isolated gene, designated ATM, mutations of which cause ataxia-telangiectasia, its genomic organization, methods for the detection of the defective gene, the purified polypeptide encoded by the defective gene, and antibodies recognizing the defective protein.
Source: selected by the editor from original sources.

Invention: Ataxia-telangiectasia gene and its genomic organization